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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1989 Aug;70(4):435–441.

Changes in phospholipid fatty acid composition and triacylglycerol content in mouse tissues after infection with bacille Calmette-Guérin.

S K Jackson 1, J M Stark 1, S Taylor 1, J L Harwood 1
PMCID: PMC2040568  PMID: 2669926

Abstract

Changes in the lipids of tissues from mice infected with bacille Calmette-Guérin (BCG) have been detected by gas-liquid chromatography. Infection with BCG resulted in (1) an increase in the polyunsaturated to saturated fatty acid ratio of phospholipids and (2) a decrease in the total triacylglycerol fatty acid content of spleen, liver and peritoneal macrophages. The alteration in fatty acid composition was significant in the phosphatidylethanolamine fraction of the phospholipids. The relation of these findings to an increased sensitivity to bacterial endotoxins is discussed.

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Selected References

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