Abstract
Marked hyperglycaemia and renal lesions developed rapidly in DBA mice infected with 10 plaque-forming units of the D-variant of encephalomyocarditis virus (EMC-D). Renal alterations were demonstrated in the glomeruli, tubular epithelium and small vessels 2 months after infection. Glomerular changes were characterized by mesangial thickening due to an increase of basement membrane-like material in the mesangial matrix. Nodular glomerular lesions were commonly observed 3 months after infection, whereas distinct thickening of the glomerular basement membrane was rarely seen. Besides these glomerular changes, glycogen inclusions in the distal tubular epithelium and medial degeneration in the arterioles were also noticed. The EMC-D-infected DBA mouse appears to be a useful experimental model for the study of human diabetic nephropathy.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bader H., Meyer D. S. The size of the juxtaglomerular apparatus in diabetic glomerulosclerosis and its correlation with arteriolosclerosis and arterial hypertension: a morphometric light microscopic study on human renal biopsies. Clin Nephrol. 1977 Jul;8(1):308–311. [PubMed] [Google Scholar]
- Burch G. E., Tsui C. Y., Harb J. M. Pancreatitis of mice infected with encephalomyocarditis virus. Pathol Microbiol (Basel) 1974;40(5):281–296. doi: 10.1159/000162546. [DOI] [PubMed] [Google Scholar]
- Burch G. E., Tsui C. Y., Harb J. M. The early renal lesions of mice infected with encephalomyocarditis virus. Lab Invest. 1972 Feb;26(2):163–172. [PubMed] [Google Scholar]
- Doi K., Onodera T., Tsuda T., Matsuzaki H., Mitsuoka T. Histopathology of BALB/c mice infected with the D variant of encephalomyocarditis virus. Br J Exp Pathol. 1988 Jun;69(3):395–401. [PMC free article] [PubMed] [Google Scholar]
- Fields B. N., Joklik W. K. Isolation and preliminary genetic and biochemical characterization of temperature-sensitive mutants of reovirus. Virology. 1969 Mar;37(3):335–342. doi: 10.1016/0042-6822(69)90217-7. [DOI] [PubMed] [Google Scholar]
- Honjo K., Doi K., Doi C., Mitsuoka T. Histopathology of streptozotocin-induced diabetic DBA/2N and CD-1 mice. Lab Anim. 1986 Oct;20(4):298–303. doi: 10.1258/002367786780808695. [DOI] [PubMed] [Google Scholar]
- KIMMELSTIEL P., KIM O. J., BERES J. Studies on renal biopsy specimens, with the aid of the electron microscope. I. Glomeruli in diabetes. Am J Clin Pathol. 1962 Sep;38:270–279. doi: 10.1093/ajcp/38.3.270. [DOI] [PubMed] [Google Scholar]
- Mauer S. M., Steffes M. W., Brown D. M. The kidney in diabetes. Am J Med. 1981 Mar;70(3):603–612. doi: 10.1016/0002-9343(81)90582-9. [DOI] [PubMed] [Google Scholar]
- Steffes M. W., Mauer S. M. Diabetic glomerulopathy in man and experimental animal models. Int Rev Exp Pathol. 1984;26:147–175. [PubMed] [Google Scholar]
- Volkmann H. P., Wehner H. Renal vessel changes in diabetic KK-mice. Virchows Arch A Pathol Anat Histopathol. 1986;409(5):669–678. doi: 10.1007/BF00713432. [DOI] [PubMed] [Google Scholar]
- Yoon J. W., McClintock P. R., Onodera T., Notkins A. L. Virus-induced diabetes mellitus. XVIII. Inhibition by a nondiabetogenic variant of encephalomyocarditis virus. J Exp Med. 1980 Oct 1;152(4):878–892. doi: 10.1084/jem.152.4.878. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yoon J. W., Rodrigues M. M., Currier C., Notkins A. L. Long-term complications of virus-induced diabetes mellitus in mice. Nature. 1982 Apr 8;296(5857):566–569. doi: 10.1038/296566a0. [DOI] [PubMed] [Google Scholar]