Abstract
An experimental model was used to study the revascularization of an ischaemic skin lesion and the effect on this process of the blood extract Solcoseryl. Under the conditions given in the experiment, restoration of the circulation was by 2 modes--re-flow in the original vessels, and neovascularization. Solcoseryl given daily i.p. encouraged the re-flow phenomenon and therefore, by improving the microcirculation and nutrition, the healing of the ischaemic lesions.
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- Charlesworth D., Harris P. L., Palmer M. K. Intra-arterial infusion of Solcoseryl: a clinical trial of a method of treatment for pre-gangrene of the lower limb. Br J Surg. 1975 May;62(5):337–339. doi: 10.1002/bjs.1800620502. [DOI] [PubMed] [Google Scholar]
- DETTLI L., STAUB H. [On the pharmacotherapeutic modification of avascular areas in the organism. Part 1. Marginal conditions in the avascular area]. Schweiz Med Wochenschr. 1960 Aug 20;90:924–929. [PubMed] [Google Scholar]
- Dettli L. Bemerkungen zum Begriff der perinektrotischen Zone. Vasa. 1973;2(4):423–425. [PubMed] [Google Scholar]
- Laszczower M. Die perinekrotische Zone. Vasa. 1973;2(4):421–422. [PubMed] [Google Scholar]
- Malaker K., Sellwood R. A. Effect of Solcoseryl on the survival of skin-grafts and the healing of donor sites in rats. Br J Surg. 1970 Mar;57(3):221–222. doi: 10.1002/bjs.1800570316. [DOI] [PubMed] [Google Scholar]
- Niinikoski J. Cellular and nutritional interactions in healing wounds. Med Biol. 1980 Dec;58(6):303–309. [PubMed] [Google Scholar]
- Niinikoski J., Renvall S. Effect of a deproteinized blood extract on experimental granulation tissue. Acta Chir Scand. 1979;145(5):287–291. [PubMed] [Google Scholar]
- Riede U. N., Rohr H. P., Sandoz P. Tierexperimentelle Studie zum Problem der Solcoseryl-Wirkung. Morphometrische Analyse der Abheilung einer normierten Verbrennungswunde. Schweiz Med Wochenschr. 1974 Feb 2;104(5):182–185. [PubMed] [Google Scholar]
- Smahel J. The healing of skin grafts. Clin Plast Surg. 1977 Jul;4(3):409–424. [PubMed] [Google Scholar]
- Szekeres L., Török L., Simon N. Wound healing and fibrinolytic activity. Vasa. 1973;2(1):81–83. [PubMed] [Google Scholar]
- Willms-Kretschmer K., Majno G. Ischemia of the skin. Electron microscopic study of vascular injury. Am J Pathol. 1969 Mar;54(3):327–353. [PMC free article] [PubMed] [Google Scholar]