Skip to main content
NCBI home page
Applied and Environmental Microbiology logoLink to Applied and Environmental Microbiology
. 1987 Sep;53(9):2082–2089. doi: 10.1128/aem.53.9.2082-2089.1987

Bactericidal activities of selected organic N-halamines.

D E Williams 1, S D Worley 1, S B Barnela 1, L J Swango 1
PMCID: PMC204062  PMID: 3314705

Abstract

The bactericidal efficacies of three organic N,N'-dihalamine disinfectants in the class of compounds termed imidazolidinones were determined for combinations of pH, temperature, and water quality treatments by using Staphylococcus aureus and Shigella boydii as test organisms. The compound 1,3-dibromo-4,4,5,5-tetramethyl-2-imidazolidinone was found to be the most rapidly acting bactericide, especially under halogen-demand-free conditions. The mixed N,N'-dihalamine 1-bromo-3-chloro-4,4,5,5-tetramethyl-2-imidazolidinone was found to be intermediate in terms of rate of disinfection, while the compound 1,3-dichloro-4,4,5,5-tetramethyl-2-imidazolidinone was observed to be the slowest acting bactericide. When overall effectiveness was judged on the basis of stability of the disinfectants along with rates of disinfection, the mixed halamine was considered to exhibit great potential for use as a disinfectant in an aqueous solution.

Full text

PDF
2082

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahmed H., Aull J. L., Williams D. E., Worley S. D. Inactivation of thymidylate synthase by chlorine disinfectants. Int J Biochem. 1986;18(3):245–250. doi: 10.1016/0020-711x(86)90113-8. [DOI] [PubMed] [Google Scholar]
  2. Barnela S. B., Worley S. D., Williams D. E. Syntheses and antibacterial activity of new N-halamine compounds. J Pharm Sci. 1987 Mar;76(3):245–247. doi: 10.1002/jps.2600760314. [DOI] [PubMed] [Google Scholar]
  3. Kaminski J. J., Huycke M. M., Selk S. H., Bodor N., Higuchi T. N-Halo derivatives V: Comparative antimicrobial activity of soft N-chloramine systems. J Pharm Sci. 1976 Dec;65(12):1737–1742. doi: 10.1002/jps.2600651211. [DOI] [PubMed] [Google Scholar]
  4. Kohl H. H., Wheatley W. B., Worley S. D., Bodor N. Antimicrobial activity of N-chloramine compounds. J Pharm Sci. 1980 Nov;69(11):1292–1295. doi: 10.1002/jps.2600691116. [DOI] [PubMed] [Google Scholar]
  5. Kosugi M., Kaminski J. J., Selk S. H., Pitman I. H., Bodor N., Higuchi T. N-Halo derivatives VI: Microbiological and chemical evaluations of 3-chloro-2-oxazolidinones. J Pharm Sci. 1976 Dec;65(12):1743–1746. doi: 10.1002/jps.2600651212. [DOI] [PubMed] [Google Scholar]
  6. LeChevallier M. W., Cameron S. C., McFeters G. A. New medium for improved recovery of coliform bacteria from drinking water. Appl Environ Microbiol. 1983 Feb;45(2):484–492. doi: 10.1128/aem.45.2.484-492.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. McFeters G. A., Cameron S. C., LeChevallier M. W. Influence of diluents, media, and membrane filters on detection fo injured waterborne coliform bacteria. Appl Environ Microbiol. 1982 Jan;43(1):97–103. doi: 10.1128/aem.43.1.97-103.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Mora E. C., Kohl H. H., Wheatley W. B., Worley S. D., Faison J. H., Burkett H. D., Bodor N. Properties of a new chloramine disinfectant and detoxicant. Poult Sci. 1982 Oct;61(10):1968–1971. doi: 10.3382/ps.0611968. [DOI] [PubMed] [Google Scholar]
  9. Williams D. E., Worley S. D., Wheatley W. B., Swango L. J. Bactericidal properties of a new water disinfectant. Appl Environ Microbiol. 1985 Mar;49(3):637–643. doi: 10.1128/aem.49.3.637-643.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Applied and Environmental Microbiology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES