Abstract
In a previous paper we have reported that the oral long-term administration of 200 mg/kd of L-tryptophan to rats with a porto-caval shunt causes significant loss of body weight, muscular hypertonicity and aggressivity, as well as marked alteration of the liver structure. We now report that tryptophan administered at the same dosage for the same length of time also induces significant alteration of the central nervous system. These results further demonstrate that high plasma levels of tryptophan are quite well tolerated by control animals but are quite toxic to rats with a porto-caval shunt. We also claim that the brain alterations observed in such animals are not secondary to liver dysfunction but to high levels of plasma tryptophan per se.
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- Bloxam D. L., Curzon G., Kantamaneni B. D., Tricklebank M. D. Effects of tryptophan and portocaval anastomosis on activity and brain tryptophan metabolism [proceedings]. Br J Pharmacol. 1977 Jun;60(2):277P–277P. [PMC free article] [PubMed] [Google Scholar]
- Bucci L., Chiavarelli R. The toxic effects of long-term, oral administration of L-tryptophan in rats with portacaval shunt. Br J Exp Pathol. 1979 Aug;60(4):389–394. [PMC free article] [PubMed] [Google Scholar]
- Cummings M. G., Soeters P. B., James J. H., Kean J. M., Fischer J. E. Regional brain indoleamine metabolism following chronic portacaval anastomosis in the rat. J Neurochem. 1976 Aug;27(2):501–509. doi: 10.1111/j.1471-4159.1976.tb12274.x. [DOI] [PubMed] [Google Scholar]
- Hindfelt B., Plum F., Duffy T. E. Effect of acute ammonia intoxication on cerebral metabolism in rats with portacaval shunts. J Clin Invest. 1977 Mar;59(3):386–396. doi: 10.1172/JCI108651. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Iob V., Mattson W. J., Jr, Sloan M., Coon W. W., Turcotte J. G., Child C. G., 3rd Alterations in plasma-free amino acids in dogs with hepatic insufficiency. Surg Gynecol Obstet. 1970 May;130(5):794–800. [PubMed] [Google Scholar]
- MASLAND W. S. INTERRELATIONSHIPS BETWEEN DIET AND WEIGHT GAIN IN RATS WITH PORTACAVAL SHUNTS. Am J Physiol. 1964 Feb;206:304–308. doi: 10.1152/ajplegacy.1964.206.2.304. [DOI] [PubMed] [Google Scholar]
- Manghani K. K., Lunzer M. R., Billing B. H., Sherlock S. Urinary and serum octopamine in patients with portal-systemic encephalopathy. Lancet. 1975 Nov 15;2(7942):943–946. doi: 10.1016/s0140-6736(75)90359-1. [DOI] [PubMed] [Google Scholar]
- McDERMOTT W. V., Jr, ADAMS R. D., RIDDELL A. G. Ammonia metabolism in man. Ann Surg. 1954 Oct;140(4):539–556. doi: 10.1097/00000658-195410000-00010. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Victor M., Adams R. D., Cole M. The acquired (non-Wilsonian) type of chronic hepatocerebral degeneration. Medicine (Baltimore) 1965 Sep;44(5):345–396. doi: 10.1097/00005792-196509000-00001. [DOI] [PubMed] [Google Scholar]
- Wasterlain C. G., Lockwood A. H., Conn M. Chronic inhibition of brain protein synthesis after portacaval shunting. A possible pathogenic mechanism in chronic hepatic encephalopathy in the rat. Neurology. 1978 Mar;28(3):233–238. doi: 10.1212/wnl.28.3.233. [DOI] [PubMed] [Google Scholar]