Skip to main content
NCBI home page
British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1982 Aug;63(4):401–407.

Ultrastructure of the lung after ventilation.

E John, M McDevitt, W Wilborn, G Cassady
PMCID: PMC2040645  PMID: 7150503

Abstract

We looked at the ultrastructure of the lung of rabbits ventilated with air moistened with nebulized water ("nebulized group"), and humidified air ("humidified group") compared to a group of controls. Both groups of ventilated rabbits had plasmalemmal vesicles that were larger than in controls. They were fewer in number (P less than 0.001) and less well defined. Early degenerative changes were noted in 6 of 9 rabbits in the nebulized group and 6 of 9 rabbits in the humidified group, while none of the rabbits in the control group were similarly affected. Interstitial oedema of varying severity was seen in 6/9 rabbits from each of the ventilated groups.

Full text

PDF
401

Images in this article

404Fig. 1
on p.404
404Fig. 2
on p.404
405Fig. 3
on p.405
405Fig. 4
on p.405
406Fig. 5
on p.406

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cottrell T. S., Levine O. R., Senior R. M., Wiener J., Spiro D., Fishman A. P. Electron microscopic alterations at the alveolar level in pulmonary edema. Circ Res. 1967 Dec;21(6):783–797. doi: 10.1161/01.res.21.6.783. [DOI] [PubMed] [Google Scholar]
  2. DeLemos R., Wolfsdorf J., Nachman R., Block A. J., Leiby G., Wilkinson H. A., Allen T., Haller J. A., Morgan W., Avery M. E. Lung injury from oxygen in lambs: the role of artificial ventilation. Anesthesiology. 1969 Jun;30(6):609–618. doi: 10.1097/00000542-196906000-00007. [DOI] [PubMed] [Google Scholar]
  3. Finegold M. J. Interstitial pulmonary edema. An electron microscopic study of the pathology of staphylococcal enterotoxemia in Rhesus monkeys. Lab Invest. 1967 Jun;16(6):912–924. doi: 10.21236/ad0811615. [DOI] [PubMed] [Google Scholar]
  4. Hayes J. A., Shiga A. Ultrastructural changes in pulmonary oedema produced experimentally with ammonium sulphate. J Pathol. 1970 Apr;100(4):281–286. doi: 10.1002/path.1711000407. [DOI] [PubMed] [Google Scholar]
  5. Horsky P. Lésions pulmonaires de la ventilation artificielle et de l'oxygénothérapie: étude expérimentale chez le chat. Respiration. 1977;34(5):278–284. doi: 10.1159/000193837. [DOI] [PubMed] [Google Scholar]
  6. John E., Ermocilla R., Golden J., Cash R., McDevitt M., Cassady G. Effects of gas temperature and particulate water on rabbit lungs during ventilation. Pediatr Res. 1980 Nov;14(11):1186–1191. doi: 10.1203/00006450-198011000-00007. [DOI] [PubMed] [Google Scholar]
  7. John E., Ermocilla R., Golden J., McDevitt M., Cassady G. Effects of intermittent positive-pressure ventilation on lungs of normal rabbits. Br J Exp Pathol. 1980 Jun;61(3):315–323. [PMC free article] [PubMed] [Google Scholar]
  8. Nash G., Blennerhassett J. B., Pontoppidan H. Pulmonary lesions associated with oxygen therapy and artifical ventilation. N Engl J Med. 1967 Feb 16;276(7):368–374. doi: 10.1056/NEJM196702162760702. [DOI] [PubMed] [Google Scholar]
  9. Nilsson R., Grossmann G., Robertson B. Lung surfactant and the pathogenesis of neonatal bronchiolar lesions induced by artificial ventilation. Pediatr Res. 1978 Apr;12(4 Pt 1):249–255. doi: 10.1203/00006450-197804000-00001. [DOI] [PubMed] [Google Scholar]
  10. Webb H. H., Tierney D. F. Experimental pulmonary edema due to intermittent positive pressure ventilation with high inflation pressures. Protection by positive end-expiratory pressure. Am Rev Respir Dis. 1974 Nov;110(5):556–565. doi: 10.1164/arrd.1974.110.5.556. [DOI] [PubMed] [Google Scholar]

Articles from British journal of experimental pathology are provided here courtesy of Wiley

RESOURCES