Abstract
The protective effect of a high dietary sodium intake in models of acute renal failure is well known. This effect may be mediated via an increased endogenous dopamine production. The effects of different salt intakes and υ-glutamyl dopa (a renal pro-drug for dopamine) on the histological changes following s.c. glycerol were studied in the rat. The protective effect on a high sodium diet was confirmed and υ-glutamyl dopa was also shown to reduce significantly the damage caused by glycerol.
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