Abstract
Antibody to rabbit kidney Fraction 3 antigen was raised in guinea-pigs. In an indirect fluorescent antibody test the guinea-pig sera showed high levels of antibody to both rabbit and rat tubular nephritogenic antigen and a much lower level of antibody against their own kidney tubular antigen. I.v. injection of this guinea-pig anti-rabbit kidney Fraction 3 antibody into rats produced immune-complex glomerulonephritis, morphologically identical to passive Heymann nephritis.
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