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. 1982 Oct;63(5):554–561.

The toxic effects of combined administration of cyclosporin A and gentamicin.

P H Whiting, J G Simpson, R J Davidson, A W Thomson
PMCID: PMC2040758  PMID: 7171480

Abstract

The toxic properties of cyclosporin A and gentamicin give alone and in combination were investigated in groups of Sprague-Dawley rats over a 7-day period. Administration of each drug on its own caused minor impairment of renal and hepatic function: cyclosporin A had additional structural effects on renal tubules and lymphoid tissue. Combined therapy resulted in acute renal failure with two distinct zones of damage in the renal proximal tubules--gentamicin-induced necrosis of the convoluted segment and cyclosporin A-related vacuolation of the straight segment--and the effects on hepatic and haematological parameters were more pronounced. The results indicate the need for caution before cyclosporin A and another potentially nephrotoxic drug and administered together and for specific monitoring or renal function where such combined therapy is considered essential.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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