Abstract
Experimental myocardial infarction of the posterolateral left ventricular wall in 2 dog hearts, the result of 1 h of occlusion of the left circumflex coronary artery followed by 4 days of reperfusion, was studied post mortem by serial histological sectioning. Microscopic examination in a transverse plane showed a zone of apparent necrotic muscle removal which formed a continuous boundary between necrotic and normal myocardium without outlying, detached "islands" of necrosis. Reconstruction of the histological transmural edge of infarction at its interface with viable subepicardial muscle demonstrated wide overlapping and angulated interdigitation of the separated tissues across the midzone of the ventricular wall. The observed 3-dimensional spatial complexity of the transmural infarct boundary may be a limiting factor in successful evaluation of this experimentally important region.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Factor S. M., Okun E. M., Kirk E. S. The histological lateral border of acute canine myocardial infarction. A function of microcirculation. Circ Res. 1981 May;48(5):640–649. doi: 10.1161/01.res.48.5.640. [DOI] [PubMed] [Google Scholar]
- Factor S. M., Sonnenblick E. H., Kirk E. S. The histologic border zone of acute myocardial infarction--islands or peninsulas? Am J Pathol. 1978 Jul;92(1):111–124. [PMC free article] [PubMed] [Google Scholar]
- Hackel D. B., Ratliff N. B., Jr A technic to estimate the quantity of infarcted myocardium post mortem. Am J Clin Pathol. 1974 Feb;61(2):242–246. doi: 10.1093/ajcp/61.2.242. [DOI] [PubMed] [Google Scholar]
- Hearse D. J., Yellon D. M. The "border zone" in evolving myocardial infarction: controversy or confusion? Am J Cardiol. 1981 Jun;47(6):1321–1334. doi: 10.1016/0002-9149(81)90266-6. [DOI] [PubMed] [Google Scholar]
- Hearse J. D., Opie L. H., Katzeff I. E., Lubbe W. F., Van der Werff T. J., Peisach M., Boulle G. Characterization of the "border zone" in acute regional ischemia in the dog. Am J Cardiol. 1977 Nov;40(5):716–726. doi: 10.1016/0002-9149(77)90187-4. [DOI] [PubMed] [Google Scholar]
- Hollis D. P., Nunnally R. L., Jacobus W. E., Taylor G. J., 4th Detection of regional ischemia in perfused beating hearts by phosphorus nuclear magnetic resonance. Biochem Biophys Res Commun. 1977 Apr 25;75(4):1086–1091. doi: 10.1016/0006-291x(77)91493-0. [DOI] [PubMed] [Google Scholar]
- Linhartová A., Anderson A. e., Jr, Foraker A. G. Radial traction and bronchiolar obstruction in pulmonary emphysema. Observed and theoretical aspects. Arch Pathol. 1971 Nov;92(5):384–391. [PubMed] [Google Scholar]
- Reimer K. A., Jennings R. B. The "wavefront phenomenon" of myocardial ischemic cell death. II. Transmural progression of necrosis within the framework of ischemic bed size (myocardium at risk) and collateral flow. Lab Invest. 1979 Jun;40(6):633–644. [PubMed] [Google Scholar]
- Reimer K. A., Lowe J. E., Rasmussen M. M., Jennings R. B. The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs. Circulation. 1977 Nov;56(5):786–794. doi: 10.1161/01.cir.56.5.786. [DOI] [PubMed] [Google Scholar]