Abstract
Snell dwarf mice are deficient in the somatomedin peptides which are mediators of growth hormone action on the skeleton. Tibial fractures in dwarf mice united within 6 weeks, however chondroid differentiation and osteogenesis at the fracture site were retarded in the first few weeks after fracture compared with normal mice. Administration of bovine growth hormone (5 micrograms daily) accelerated the repair process and 2 micrograms thyroxine daily resulted in rapid callus formation and ossification indistinguishable from normal controls. Normal somatomedin levels are not therefore essential for adequate fracture healing in Snell dwarf mice. The acceleration resulting from growth hormone and thyroxine administration may be due to an increased production of somatomedins locally or systemically or by direct action on connective tissue.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Harris W. H., Heaney R. P., Jowsey J., Cockin J., Akins C., Graham J., Weinberg E. H. Growth hormone: the effect on skeletal renewal in the adult dog. I. Morphometric studies. Calcif Tissue Res. 1972;10(1):1–13. doi: 10.1007/BF02012530. [DOI] [PubMed] [Google Scholar]
- Herold H. Z., Hurvitz A., Tadmor A. The effect of growth hormone on the healing of experimental bone defects. Acta Orthop Scand. 1971;42(5):377–384. doi: 10.3109/17453677108989058. [DOI] [PubMed] [Google Scholar]
- Holder A. T., Wallis M. Actions of growth hormone, prolactin and thyroxine on serum somatomedin-like activity and growth in hypopituitary dwarf mice. J Endocrinol. 1977 Aug;74(2):223–229. doi: 10.1677/joe.0.0740223. [DOI] [PubMed] [Google Scholar]
- Hsu J. D., Robinson R. A. Studies on the healing of long-bone fractures in hereditary pituitary insufficient mice. J Surg Res. 1969 Sep;9(9):535–536. doi: 10.1016/0022-4804(69)90131-0. [DOI] [PubMed] [Google Scholar]
- Isaksson O. G., Jansson J. O., Gause I. A. Growth hormone stimulates longitudinal bone growth directly. Science. 1982 Jun 11;216(4551):1237–1239. doi: 10.1126/science.7079756. [DOI] [PubMed] [Google Scholar]
- Misol S., Samaan N., Ponseti I. V. Growth hormone in delayed fracture union. Clin Orthop Relat Res. 1971 Jan;74:206–208. [PubMed] [Google Scholar]
- Nichols J. T., Toto P. D., Choukas N. C. The proliferative capacity and DNA synthesis of osteoblasts during fracture repair in normal and hypophysectomized rats. Oral Surg Oral Med Oral Pathol. 1968 Mar;25(3):418–426. doi: 10.1016/0030-4220(68)90017-0. [DOI] [PubMed] [Google Scholar]
- Sinha Y. N., Salocks C. B., Vanderlaan W. P. Pituitary and serum concentrations of prolactin and GH in Snell dwarf mice. Proc Soc Exp Biol Med. 1975 Oct;150(1):207–210. doi: 10.3181/00379727-150-39003. [DOI] [PubMed] [Google Scholar]
- Snell G. D. DWARF, A NEW MENDELIAN RECESSIVE CHARACTER OF THE HOUSE MOUSE. Proc Natl Acad Sci U S A. 1929 Sep 15;15(9):733–734. doi: 10.1073/pnas.15.9.733. [DOI] [PMC free article] [PubMed] [Google Scholar]
- van Buul-Offers S., Van den Brande J. L. Cellular growth in organs of dwarf mice during treatment with growth hormone, thyroxine and plasma fractions containing somatomedin activity. Acta Endocrinol (Copenh) 1982 Jan;99(1):150–160. doi: 10.1530/acta.0.0990150. [DOI] [PubMed] [Google Scholar]
- van Buul S., Van den Brande J. The Snell-dwarfmouse. I. General growth pattern, before and during growth hormone and thyroxine therapy. Acta Endocrinol (Copenh) 1978 Dec;89(4):632–645. [PubMed] [Google Scholar]