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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1984 Apr;65(2):181–190.

Spontaneous hypertension and hypertensive renal disease in the fawn-hooded rat.

M H Kuijpers, E Gruys
PMCID: PMC2040964  PMID: 6370289

Abstract

The fawn-hooded (FH) rat, a strain characterized by a platelet storage-pool disease, developed focal and segmental glomerulosclerosis at the age of 2-3 months (males) and approximately 6 months (females). Male animals died spontaneously at 11-13 months, and females at 15 months of age, both with overt malignant nephrosclerosis. During the first half year of life focal glomeruli showed depositions of IgG, IgA, IgM, C3 and fibrinogen in a segmental pattern and mainly in mesangial areas. Mesangial IgG and IgA were already demonstrable at the age of 5 weeks. On electron microscopy no electron-dense deposits suggestive of immune complexes were found. Mean arterial blood pressure in 5.5-month-old male FH rats was increased compared with that of matched Wistar rats. One-year-old FH rats had severe hypertension. The presumed relationship between the hypertension, the renal lesions and the blood platelet defect is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aarden L. A., de Groot E. R., Feltkamp T. E. Immunology of DNA. III. Crithidia luciliae, a simple substrate for the determination of anti-dsDNA with the immunofluorescence technique. Ann N Y Acad Sci. 1975 Jun 30;254:505–515. doi: 10.1111/j.1749-6632.1975.tb29197.x. [DOI] [PubMed] [Google Scholar]
  2. BERG B. N. SPONTANEOUS NEPHROSIS, WITH PROTEINURIA, HYPERGLOBULINEMIA, AND HYPERCHOLESTEROLEMIA IN THE RAT. Proc Soc Exp Biol Med. 1965 Jun;119:417–420. doi: 10.3181/00379727-119-30199. [DOI] [PubMed] [Google Scholar]
  3. Barcelli U., Rademacher R., Ooi Y. M., Ooi B. S. Modification of glomerular immune complex deposition in mice by activation of the reticuloendothelial system. J Clin Invest. 1981 Jan;67(1):20–27. doi: 10.1172/JCI110013. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Bolton W. K., Benton F. R., Maclay J. G., Sturgill B. C. Spontaneous glomerular sclerosis in aging Sprague-Dawley rats. I. Lesions associated with mesangial IgM deposits. Am J Pathol. 1976 Nov;85(2):277–302. [PMC free article] [PubMed] [Google Scholar]
  5. Coccheri S., Fiorentini P. Platelet adhesiveness and aggregation in hypertensive patients. Acta Med Scand Suppl. 1971;525:273–275. doi: 10.1111/j.0954-6820.1972.tb05842.x. [DOI] [PubMed] [Google Scholar]
  6. Compston J. E., Horton L. W., Laker M. F., Ayers A. B., Woodhead J. S., Bull H. J., Gazet J. C., Pilkington T. R. Bone disease after jejuno-ileal bypass for obesity. Lancet. 1978 Jul 1;2(8079):1–4. doi: 10.1016/s0140-6736(78)91318-1. [DOI] [PubMed] [Google Scholar]
  7. Dixon R. H., Rosse W. F. Mechanism of complement-mediated activation of human blood platelets in vitro: comparison of normal and paroxysmal nocturnal hemoglobinuria platelets. J Clin Invest. 1977 Feb;59(2):360–368. doi: 10.1172/JCI108648. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Duffy J. L., Cinque T., Grishman E., Churg J. Intraglomerular fibrin, platelet aggregation, and subendothelial deposits in lipoid nephrosis. J Clin Invest. 1970 Feb;49(2):251–258. doi: 10.1172/JCI106234. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Habib R. Editorial: Focal glomerular sclerosis. Kidney Int. 1973 Dec;4(6):355–361. doi: 10.1038/ki.1973.131. [DOI] [PubMed] [Google Scholar]
  10. Kincaid-Smith P. Coagulation and renal disease. Kidney Int. 1972 Oct;2(4):183–190. doi: 10.1038/ki.1972.93. [DOI] [PubMed] [Google Scholar]
  11. Kreisberg J. I., Karnovsky M. J. Focal glomerular sclerosis in the fawn-hooded rat. Am J Pathol. 1978 Sep;92(3):637–652. [PMC free article] [PubMed] [Google Scholar]
  12. Michael A. F., Keane W. F., Raij L., Vernier R. L., Mauer S. M. The glomerular mesangium. Kidney Int. 1980 Feb;17(2):141–154. doi: 10.1038/ki.1980.18. [DOI] [PubMed] [Google Scholar]
  13. Michels L. D., Davidman M., Keane W. F. The effects of chronic mesangial immune injury on glomerular function. J Lab Clin Med. 1980 Sep;96(3):396–407. [PubMed] [Google Scholar]
  14. Miller K., Dresner I. G., Michael A. F. Localization of platelet antigens in human kidney disease. Kidney Int. 1980 Oct;18(4):472–479. doi: 10.1038/ki.1980.160. [DOI] [PubMed] [Google Scholar]
  15. Olivetti G., Kithier K., Giacomelli F., Wiener J. Glomerular permeability to endogenous proteins in the rat: effects of acute hypertension. Lab Invest. 1981 Feb;44(2):127–137. [PubMed] [Google Scholar]
  16. Parbtani A., Cameron J. S. Platelet and plasma serotonin concentration in glomerulonephritis I. Thromb Res. 1979;15(1-2):109–125. doi: 10.1016/0049-3848(79)90057-4. [DOI] [PubMed] [Google Scholar]
  17. Tschopp T. B., Zucker M. B. Hereditary defect in platelet function in rats. Blood. 1972 Aug;40(2):217–226. [PubMed] [Google Scholar]

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