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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1985 Apr;66(2):173–183.

Clinical chemical responses to experimental airborne legionellosis in the guinea-pig.

P Hambleton, N E Bailey, R B Fitzgeorge, A Baskerville
PMCID: PMC2041043  PMID: 2580546

Abstract

Legionella pneumophila infection of guinea-pigs by the aerosol route with either of two strains, one (serogroup I) giving an acute the other (serogroup 3) giving a protracted illness, induced a pyrexia and similar pneumonic lesions. With both strains there was a bacteraemia with early decreases in serum iron and zinc and increases in serum copper concentrations. Marked changes in other serum components were evident only in those animals which had protracted illness (serogroup 3-infected animals). These included transient increases in aminotransferase, creatine kinase and sorbitol dehydrogenase activities and triglyceride levels, together with gradual decreases in alkaline phosphatase and leucine aminopeptidase activities. Serum lysozyme activity and acute-phase protein synthesis increased, as did the ratio of phenylalanine to tyrosine. The findings confirm the relevance of the aerosol-infected guinea-pig model for the investigation of the disease processes and evaluation of therapeutic measures for use in man.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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