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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1976 Jun;57(3):274–280.

Age and sex differences in the response of lymph node post-capillary venules in mice infected with Toxoplasma gondii.

L Henry, K A Beverley
PMCID: PMC2041072  PMID: 952728

Abstract

Groups of male and female mice of varying ages were infected with a low-virulence strain of Toxoplasma gondii and killed 3 weeks and 6 weeks after infection. The lymph nodes of the female group showed a greater prominence of the endothelial cells of the post-capillary venules. This difference was most marked at the age of 15 weeks and least at 30 or more weeks. The same sex difference was demonstrated in control mice although to a lesser extent. The possible role is discussed of the effect of female sex hormones on vascular endothelium in modifying the development of an immune response and in explaining the observed female preponderance in human cases of auto-immune disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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