Skip to main content
British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1976 Jun;57(3):281–285.

Biochemical effects of asbestiform minerals on lung fibroblast cultures.

P M Hext, R J Richards
PMCID: PMC2041080  PMID: 952729

Abstract

The ability of different types of asbestiform minerals to enhance or suppress the levels of fibrous collagen in cultures of lung fibroblasts was tested. All commercially important asbestos dusts produced both effects, a lower dose favouring a fibrogenic response whereas a higher dose favoured an opposite effect.

Full text

PDF
281

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BURTON K. A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem J. 1956 Feb;62(2):315–323. doi: 10.1042/bj0620315. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. CERIOTTI G. Determination of nucleic acids in animal tissues. J Biol Chem. 1955 May;214(1):59–70. [PubMed] [Google Scholar]
  3. Desai R., Hext P., Richards R. The prevention of asbestos-induced hemolysis. Life Sci. 1975 Jun 15;16(12):1931–1938. doi: 10.1016/0024-3205(75)90303-3. [DOI] [PubMed] [Google Scholar]
  4. Hamerman D., Todaro G. J., Green H. The production of hyaluronate by spontaneously established cell lines and viral transformed lines of fibroblastic origin. Biochim Biophys Acta. 1965 Nov 1;101(3):343–351. doi: 10.1016/0926-6534(65)90013-8. [DOI] [PubMed] [Google Scholar]
  5. Harington J. S., Miller K., Macnab G. Hemolysis by asbestos. Environ Res. 1971 Apr;4(2):95–117. doi: 10.1016/0013-9351(71)90038-7. [DOI] [PubMed] [Google Scholar]
  6. Kurtz M. J., Stidworthy G. H. Control over acid mucopolysaccharide production of cells in vitro. Biochim Biophys Acta. 1975 Jul 14;399(1):90–100. doi: 10.1016/0304-4165(75)90215-9. [DOI] [PubMed] [Google Scholar]
  7. Morgan A., Lally A. E., Holmes A. Some observations on the distribution of trace metals in chrysotile asbestos. Ann Occup Hyg. 1973 Nov;16(3):231–240. doi: 10.1093/annhyg/16.3.231. [DOI] [PubMed] [Google Scholar]
  8. Motomiya M., Arai H., Sato H., Yokosawa A., Nagai H. Increase of dermatan sulfate in a case of pulmonary fibrosis. Tohoku J Exp Med. 1975 Apr;115(4):361–365. doi: 10.1620/tjem.115.361. [DOI] [PubMed] [Google Scholar]
  9. OYAMA V. I., EAGLE H. Measurement of cell growth in tissue culture with a phenol reagent (folin-ciocalteau). Proc Soc Exp Biol Med. 1956 Feb;91(2):305–307. doi: 10.3181/00379727-91-22245. [DOI] [PubMed] [Google Scholar]
  10. Obrink B. The influence of glycosaminoglycans on the formation of fibers from monomeric tropocollagen in vitro. Eur J Biochem. 1973 Apr 2;34(1):129–137. doi: 10.1111/j.1432-1033.1973.tb02739.x. [DOI] [PubMed] [Google Scholar]
  11. Richards G. M. Modifications of the diphenylamine reaction giving increased sensitivity and simplicity in the estimation of DNA. Anal Biochem. 1974 Feb;57(2):369–376. doi: 10.1016/0003-2697(74)90091-8. [DOI] [PubMed] [Google Scholar]
  12. Richards R. J., Hext P. M., Blundell G., Henderson W. J., Volcani B. E. Ultrastructural changes in lung fibroblast cultures exposed to chrysotile asbestos. Br J Exp Pathol. 1974 Jun;55(3):275–281. [PMC free article] [PubMed] [Google Scholar]
  13. Richards R. J., Wusteman F. S., Dodgson K. S. The direct effects of dusts on lung fibroblasts grown in vitro. Life Sci I. 1971 Oct 15;10(20):1149–1159. doi: 10.1016/0024-3205(71)90275-x. [DOI] [PubMed] [Google Scholar]

Articles from British journal of experimental pathology are provided here courtesy of Wiley

RESOURCES