Abstract
Glomerular basement membranes showed strong silver labelling on electron microscopy in NZB/NZW mice fed 12 mmol AgNO3 for 6 weeks at ages from 1-7 months. Although some silver granules were seen within mesangial immune deposits following their concurrent deposition, silver was usually deposited in electron-lucent areas around pre-existing deposits, or formed a boundary to an expanded mesangium when immune deposits subsequently developed. Immune deposits in capillary loops occurred on the outer or inner aspect of the zone of silver labelling.
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Selected References
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- Day W. A., Hunt J. S., McGiven A. R. Silver deposition in mouse glomeruli. Pathology. 1976 Jul;8(3):201–204. doi: 10.3109/00313027609059000. [DOI] [PubMed] [Google Scholar]
- Hunt J. S., McGiven A. R., Day W. A. Immmune complex glomerular disease in argyric mice. Pathology. 1976 Jul;8(3):205–210. doi: 10.3109/00313027609059001. [DOI] [PubMed] [Google Scholar]
- Lambert P. H., Dixon F. J. Pathogenesis of the glomerulonephritis of NZB/W mice. J Exp Med. 1968 Mar 1;127(3):507–522. doi: 10.1084/jem.127.3.507. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McGiven A. R., Hicks J. D. The development of renal lesions in NZB-NZW mice immunohistological studies. Br J Exp Pathol. 1967 Jun;48(3):302–304. [PMC free article] [PubMed] [Google Scholar]
- McGiven A. R., Ironside P. N. Elution of antinuclear factor from renal lesions of NZB-NZW mice. Clin Exp Immunol. 1968 Sep;3(7):665–669. [PMC free article] [PubMed] [Google Scholar]
- Nairn R. C., McGiven A. R., Ironside P. N., Norins L. C. Plasma proteins in the glomerular lesions of NZB/NZW mice. Br J Exp Pathol. 1966 Feb;47(1):99–103. [PMC free article] [PubMed] [Google Scholar]
- Walker F. Experimental argyria: a model for basement membrane studies. Br J Exp Pathol. 1971 Dec;52(6):589–593. [PMC free article] [PubMed] [Google Scholar]