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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1976 Dec;57(6):645–652.

Experimental canine distemper infection as a means of demonstrating latent effects of subacute lead intoxication.

D J White, S McLeod
PMCID: PMC2041248  PMID: 1008996

Abstract

Observations on the response of the body to experimental infection with distemper virus in dogs previously dosed subacutely with lead have demonstrated a latent effect of lead on several body systems. Effects which indicated a relationship to earlier treatment with lead included evidence for stimulation of haemoglobin synthesis, changes to red blood cells resulting in increased destruction, increased vulnerability of the parenchymatous cells of the liver to damage, reduction in the weight of the skeleton and thyroid, an increase in weight of the thymus and brain and histopathological changes in the thymus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Clasen R. A., Hartmann J. F., Starr A. J., Coogan P. S., Pandolfi S., Laing I., Becker R., Hass G. M. Electron microscopic and chemical studies of the vascular changes and edema of lead encephalopathy. A comparative study of the human and experimental disease. Am J Pathol. 1974 Feb;74(2):215–240. [PMC free article] [PubMed] [Google Scholar]
  2. HENRY R. J., CHIAMORI N., GOLUB O. J., BERKMAN S. Revised spectrophotometric methods for the determination of glutamic-oxalacetic transaminase, glutamic-pyruvic transaminase, and lactic acid dehydrogenase. Tech Bull Regist Med Technol. 1960 Sep;30:149–166. [PubMed] [Google Scholar]
  3. Henry L. Involution of the human thymus. J Pathol Bacteriol. 1967 Apr;93(2):661–671. doi: 10.1002/path.1700930227. [DOI] [PubMed] [Google Scholar]
  4. Hernberg S., Nikkanen J. Enzyme inhibition by lead under normal urban conditions. Lancet. 1970 Jan 10;1(7637):63–64. doi: 10.1016/s0140-6736(70)91846-5. [DOI] [PubMed] [Google Scholar]
  5. Hoffmann E. O., Di Luzio N. R., Holper K., Brettschneider L., Coover J. Ultrastructural changes in the liver of baboons following lead and endotoxin administration. Lab Invest. 1974 Mar;30(3):311–319. [PubMed] [Google Scholar]
  6. LEVINE J. B., ZAK B. AUTOMATED DETERMINATION OF SERUM TOTAL CHOLESTEROL. Clin Chim Acta. 1964 Oct;10:381–384. doi: 10.1016/0009-8981(64)90073-7. [DOI] [PubMed] [Google Scholar]
  7. MARSDEN H. B., WILSON V. K. Lead poisoning in children; correlation of clinical and pathological findings. Br Med J. 1955 Feb 5;1(4909):324–326. doi: 10.1136/bmj.1.4909.324. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. MARSH W. H., FINGERHUT B., MILLER H. AUTOMATED AND MANUAL DIRECT METHODS FOR THE DETERMINATION OF BLOOD UREA. Clin Chem. 1965 Jun;11:624–627. [PubMed] [Google Scholar]
  9. Morgenstern S., Oklander M., Auerbach J., Kaufman J., Klein B. Automated determination of serum glutamic oxaloacetic transaminase. Clin Chem. 1966 Feb;12(2):95–111. [PubMed] [Google Scholar]
  10. Prydie J. Studies with an attenuated canine distemper vaccine derived from chick embryo cultures. Res Vet Sci. 1968 Sep;9(5):443–452. [PubMed] [Google Scholar]
  11. Secchi G. C., Alessio L., Spreafico F. Serum enzymatic activities in experimental lead poisoning. Enzyme. 1971;12(1):63–69. doi: 10.1159/000459515. [DOI] [PubMed] [Google Scholar]
  12. Stowe H. D., Goyer R. A., Krigman M., Wilson M., Cates M. Experimental oral lead toxicity in young dogs. Clinical and morphologic effects. Arch Pathol. 1973 Feb;95(2):106–116. [PubMed] [Google Scholar]
  13. Trejo R. A., Di Luzio N. R., Loose L. D., Hoffman E. Reticuloendothelial and hepatic functional alterations following lead acetate administration. Exp Mol Pathol. 1972 Oct;17(2):145–158. doi: 10.1016/0014-4800(72)90064-0. [DOI] [PubMed] [Google Scholar]
  14. Waldron H. A. The anaemia of lead poisoning: a review. Br J Ind Med. 1966 Apr;23(2):83–100. doi: 10.1136/oem.23.2.83. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. White D. J., Marshall A. J., McLeod S. The influence of experimental distemper infection on the distribution of lead in dogs previously subacutely intoxicated with lead carbonate. Br J Exp Pathol. 1975 Dec;56(6):544–548. [PMC free article] [PubMed] [Google Scholar]
  16. Zinkl J. G., Bush R. M., Cornelius C. E., Freedland R. A. Comparative studies on plasma and tissue sorbitol, glutamic, lactic and hydroxybutyric dehydrogenase and transaminase activities in the dog. Res Vet Sci. 1971 May;12(3):211–214. [PubMed] [Google Scholar]

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