Abstract
Two-way mixed lymphocyte reactivity (2-way-MLR) between maternal and fetal lymphocytes in vitro, and one-way mixed lymphocyte reactivity (1-way-MLR) of maternal lymphocytes (responders) to stimulation by mitomycin-treated fetal lymphocytes (stimulators), were investigated in normal and pre-eclamptic pregnancies. No relationship was observed between pre-eclampsia and the 2-way-MLR. The 1-way-MLR was lowest in normal pregnancy, higher in mild pre-eclampsia, and highest in severe pre-eclampsia, although none of these differences were statistically significant.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Finn R., St Hill C. A., Govan A. J., Ralfs I. G., Gurney F. J., Denye V. Immunological responses in pregnancy and survival of fetal homograft. Br Med J. 1972 Jul 15;3(5819):150–152. doi: 10.1136/bmj.3.5819.150. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gaugas J. M., Jones E., Curzen P. Spontaneous lymphocyte transformation in pregnancies complicated by pre-eclampsia. Am J Obstet Gynecol. 1975 Feb 15;121(4):542–544. doi: 10.1016/0002-9378(75)90089-7. [DOI] [PubMed] [Google Scholar]
- Jones E., Curzen P., Gaugas J. M. Suppressive activity of pregnancy plasma on the mixed lymphocyte reaction. J Obstet Gynaecol Br Commonw. 1973 Jul;80(7):603–607. doi: 10.1111/j.1471-0528.1973.tb16033.x. [DOI] [PubMed] [Google Scholar]
- Jones E., Curzen P. The immunological reactivity of maternal lymphocytes in pregnancy. J Obstet Gynaecol Br Commonw. 1973 Jul;80(7):608–610. doi: 10.1111/j.1471-0528.1973.tb16034.x. [DOI] [PubMed] [Google Scholar]
- Kasakura S. A factor in maternal plasma during pregnancy that suppresses the reactivity of mixed leukocyte cultures. J Immunol. 1971 Nov;107(5):1296–1301. [PubMed] [Google Scholar]
- PLATT R., STEWART A. E., EMERY E. W. The aetiology, incidence, and heredity of pre-eclamptic toxaemia of pregnancy. Lancet. 1958 Mar 15;1(7020):552–556. doi: 10.1016/s0140-6736(58)91192-9. [DOI] [PubMed] [Google Scholar]
- Pagé D., Posen G., Stewart T., Harris J. Immunological detection of renal allograft rejection in man: increased deoxyribonucleic acid synthesis by peripheral lymphoid cells. Transplantation. 1971 Nov;12(5):341–347. doi: 10.1097/00007890-197111000-00001. [DOI] [PubMed] [Google Scholar]
- Rode H. N., Gordon J. Macrophages in the mixed leukocyte culture reaction (MLC). Cell Immunol. 1974 Jul;13(1):87–94. doi: 10.1016/0008-8749(74)90229-9. [DOI] [PubMed] [Google Scholar]
- Terasaki P. I., Mickey M. R., Yamazaki J. N., Vredevoe D. Maternal-fetal incompatibility. I. Incidence of HL-A antibodies and possible association with congenital anomalies. Transplantation. 1970 Jun;9(6):538–543. [PubMed] [Google Scholar]