Skip to main content
PMC home page
British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1977 Apr;58(2):140–146.

Portacaval transposition and subsequent partial hepatectomy in the rat: effects on liver atrophy, hypertrophy and regenerative hyperplasia.

J Guest, C J Ryan, I S Benjamin, L H Blumgart
PMCID: PMC2041272  PMID: 861164

Abstract

Portacaval transposition diverts portal blood from the liver. It allows systemic venous blood to perfuse the portal bed. Body weight and liver weight have been followed before and after portacaval transposition and control procedures in rats, and the DNA activity ratio studied in the liver of rats after partial hepatectomy in protacavally transposed animals. The results suggest that the liver atrophy seen after portal diversion is a result of diversion of trophic substances in the portal blood rather than of a decrease in absolute liver flow. Recovery of liver weight after partial hepatectomy in portacavally transposed animals occurs within the same time as in control animals, and the time course and magnitude of regenerative hyperplasia, as assessed by liver DNA activity ratio, is unimpaired.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BUCHER N. L. REGENERATION OF MAMMALIAN LIVER. Int Rev Cytol. 1963;15:245–300. doi: 10.1016/s0074-7696(08)61119-5. [DOI] [PubMed] [Google Scholar]
  2. FISHER B., LEE S. H., FISHER E. R., SAFFER E. Liver regeneration following portacaval shunt. Surgery. 1962 Jul;52:88–102. [PubMed] [Google Scholar]
  3. HEER F. W., SILVIUS D. E., HARPER H. A. The relation between hepatic flow and function in normal dogs and dogs with cirrhosis after portacaval shunt or transposition. Surg Forum. 1960;11:282–284. [PubMed] [Google Scholar]
  4. Hyde T. A., Davis J. C. The effects of cortisol and chlorazanil on the mitotic rate in mouse liver and skin. Eur J Cancer. 1966 Aug;2(3):227–230. doi: 10.1016/0014-2964(66)90058-2. [DOI] [PubMed] [Google Scholar]
  5. JAFFE J. J. Diurnal mitotic periodicity in regenerating rat liver. Anat Rec. 1954 Dec;120(4):935–954. doi: 10.1002/ar.1091200408. [DOI] [PubMed] [Google Scholar]
  6. Ryan C. J., Benjamin I. S., Blumgart L. H. Portacaval transposition in the rat: a new technique and its effects on liver and body weight. Br J Surg. 1974 Mar;61(3):224–228. doi: 10.1002/bjs.1800610313. [DOI] [PubMed] [Google Scholar]
  7. STARZL T. E., SCANLON W. A., SHOEMAKER W. C., THORNTON F. H., WENDEL R. M., SCHLACHTER L. Studies on hepatic blood flow and the rate of bromsulphalein clearance in dogs with portacaval transposition. Surgery. 1962 Oct;52:660–663. [PMC free article] [PubMed] [Google Scholar]
  8. Starzl T. E., Porter K. A., Kashiwagi N. Portal hepatotrophic factors, diabetes mellitus and acute liver atrophy, hypertrophy and regeneration. Surg Gynecol Obstet. 1975 Dec;141(6):843–858. [PMC free article] [PubMed] [Google Scholar]
  9. Starzl T. E., Watanabe K., Porter K. A., Putnam C. W. Effects of insulin, glucagon, and insuling/glucagon infusions on liver morphology and cell division after complete portacaval shunt in dogs. Lancet. 1976 Apr 17;1(7964):821–825. doi: 10.1016/s0140-6736(76)90477-3. [DOI] [PubMed] [Google Scholar]
  10. WEINBREN K. The portal blood supply and regeneration of the rat liver. Br J Exp Pathol. 1955 Dec;36(6):583–591. [PMC free article] [PubMed] [Google Scholar]
  11. WEINBREN K., WOODWARD E. DELAYED INCORPORATION OF 32P FROM ORTHOPHOSPHATE INTO DEOXYRIBONUCLEIC ACID OF RAT LIVER AFTER SUBTOTAL HEPATECTOMY. Br J Exp Pathol. 1964 Aug;45:442–449. [PMC free article] [PubMed] [Google Scholar]
  12. Weinbren K., Arden G. M., Stirling G. A. Increased incorporation of 3H-thymidine into rat liver DNA after handling of liver lobes. Br J Exp Pathol. 1969 Dec;50(6):540–547. [PMC free article] [PubMed] [Google Scholar]
  13. Weinbren K., Stirling G. A., Washington S. L. The development of a proliferative response in liver parenchyma deprived of portal blood flow. Br J Exp Pathol. 1972 Feb;53(1):54–58. [PMC free article] [PubMed] [Google Scholar]
  14. Weinbren K., Washington S. L., Smith C. Y. The response of the rat liver to alterations in total portal blood flow. Br J Exp Pathol. 1975 Apr;56(2):148–156. [PMC free article] [PubMed] [Google Scholar]

Articles from British journal of experimental pathology are provided here courtesy of Wiley

RESOURCES