Skip to main content
NCBI home page
British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1977 Dec;58(6):670–677.

Thrombosis induced in vivo in the mesenteric artery of normal and thrombocytopenic rats, an electron-microscopic study of the early arterial wall reaction.

P R Potvliege, R H Bourgain
PMCID: PMC2041302  PMID: 607987

Abstract

Arteries taken from 1 to 3 days after local thrombosis had been induced by the passage of a weak electric current followed by the topical administration of ADP were studied by electronmicroscopy. The characteristic changes observed during this period included total disappearance of pre-existing thrombi, rapid reconstitution of the endothelium and important hypertrophy of smooth muscle cells in the media. Thrombocytopenia induced by the administration of antiplatelet serum produced no alterations in untreated arteries. When it was coupled to thrombus induction, healing of injured endothelial and smooth muscle cells was grossly impaired, hypertrophy of the media was absent and fibrin infiltrated the arterial wall at the site of thrombus induction. These results bring support to the view that blood platelets play an important role in the induction of the regeneration response of injured arterial cells.

Full text

PDF
670

Images in this article

672Fig. 1
on p.672
672Fig. 2
on p.672
673Fig. 3
on p.673
674Fig. 4
on p.674
675Fig. 5
on p.675

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Benditt E. P. The origin of atherosclerosis. Sci Am. 1977 Feb;236(2):74–85. doi: 10.1038/scientificamerican0277-74. [DOI] [PubMed] [Google Scholar]
  2. Gimbrone M. A., Jr, Aster R. H., Cotran R. S., Corkery J., Jandl J. H., Folkman J. Preservation of vascular integrity in organs perfused in vitro with a platelet-rich medium. Nature. 1969 Apr 5;222(5188):33–36. doi: 10.1038/222033a0. [DOI] [PubMed] [Google Scholar]
  3. Gore I., Takada M., Austin J. Ultrastructural basis of experimental thrombocytopenic purpura. Arch Pathol. 1970 Sep;90(3):197–205. [PubMed] [Google Scholar]
  4. Jorgensen L., Hovig T., Rowsell H. C., Mustard J. F. Adenosine diphosphate-induced platelet aggregation and vascular injury in swine and rabbits. Am J Pathol. 1970 Nov;61(2):161–176. [PMC free article] [PubMed] [Google Scholar]
  5. Lough J., Moore S. Endothelial injury induced by thrombin or thrombi. Lab Invest. 1975 Aug;33(2):130–135. [PubMed] [Google Scholar]
  6. Lough J., Moore S. Platelet embolic injury; the healing process. Exp Mol Pathol. 1972 Oct;17(2):132–144. doi: 10.1016/0014-4800(72)90063-9. [DOI] [PubMed] [Google Scholar]
  7. Malczak H. T., Buck R. C. Regeneration of endothelium in rat aorta after local freezing. A scanning electron microscopic study. Am J Pathol. 1977 Jan;86(1):133–148. [PMC free article] [PubMed] [Google Scholar]
  8. Moore S., Friedman R. J., Singal D. P., Gauldie J., Blajchman M. A., Roberts R. S. Inhibition of injury induced thromboatherosclerotic lesions by anti-platelet serum in rabbits. Thromb Haemost. 1976 Feb 29;35(1):70–81. [PubMed] [Google Scholar]
  9. Moore S., Lough J. Lipid accumulation in renal arterioles due to platelet aggregate embolism. Am J Pathol. 1970 Feb;58(2):283–293. [PMC free article] [PubMed] [Google Scholar]
  10. Potvliege P. R., Bourgain R. H. Thrombosis induced in vivo in the mesenteric artery of rats. An electron microscopic study of the initial phases. Br J Exp Pathol. 1976 Dec;57(6):722–732. [PMC free article] [PubMed] [Google Scholar]
  11. Ross R., Glomset J. A. Atherosclerosis and the arterial smooth muscle cell: Proliferation of smooth muscle is a key event in the genesis of the lesions of atherosclerosis. Science. 1973 Jun 29;180(4093):1332–1339. doi: 10.1126/science.180.4093.1332. [DOI] [PubMed] [Google Scholar]
  12. Ross R., Glomset J. A. The pathogenesis of atherosclerosis (first of two parts). N Engl J Med. 1976 Aug 12;295(7):369–377. doi: 10.1056/NEJM197608122950707. [DOI] [PubMed] [Google Scholar]
  13. Sharma H. M., Moore S., Merrick H. W., Smith M. R. Platelets in early hyperacute allograft rejection in kidneys and their modification by sulfinpyrazone (Anturan) therapy. An experimental study. Am J Pathol. 1972 Mar;66(3):445–460. [PMC free article] [PubMed] [Google Scholar]
  14. Sharma H. M., Rosensweig J., Chatterjee S., Moore S., De Champlain M. L. Platelets in hyperacute rejection of heterotopic cardiac allografts in presensitized dogs. An experimental study. Am J Pathol. 1973 Feb;70(2):155–174. [PMC free article] [PubMed] [Google Scholar]
  15. Walton K. W. Pathogenetic mechanisms in atherosclerosis. Am J Cardiol. 1975 Apr;35(4):542–558. doi: 10.1016/0002-9149(75)90839-5. [DOI] [PubMed] [Google Scholar]

Articles from British journal of experimental pathology are provided here courtesy of Wiley

RESOURCES