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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1978 Feb;59(1):76–84.

Effects of fever on host defense mechanisms after infection in the lizard Dipsosaurus dorsalis.

H A Bernheim, P T Bodel, P W Askenase, E Atkins
PMCID: PMC2041320  PMID: 638032

Abstract

Fever has never been proven beneficial in mammals, although it enhances survival in the lizard D. dorsalis infected with Aeromonas hydrophila. We examined the course of the infection and the function of host defence in febrile (41 degrees) and afebrile (35 degrees or 38 degrees) animals using this model. Infected, febrile lizards had sterile blood cultures, and 1-2 logs fewer bacteria in body tissues 6-12 h after infection. Granulocytes appeared early and in large numbers at the site of inoculation in febrile, but not afebrile, animals. We were unable to demonstrate effects of this small range of temperatures on in vitro growth rates of bacteria, on lizard granulocyte chemotactic or phagocytic functions, or upon serum antibody levels. Our results suggest that fever enhances some aspect of the early inflammatory response, leading to increased leucocyte emigration at the local site and containment of the infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ATWOOD R. P., KASS E. H. RELATIONSHIP OF BODY TEMPERATURE TO THE LETHAL ACTION OF BACTERIAL ENDOTOXIN. J Clin Invest. 1964 Feb;43:151–169. doi: 10.1172/JCI104899. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BENNETT I. L., Jr, NICASTRI A. Fever as a mechanism of resistance. Bacteriol Rev. 1960 Mar;24(1):16–34. doi: 10.1128/br.24.1.16-34.1960. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bernheim H. A., Kluger M. J. Fever: effect of drug-induced antipyresis on survival. Science. 1976 Jul 16;193(4249):237–239. doi: 10.1126/science.935867. [DOI] [PubMed] [Google Scholar]
  4. CONNOR D. G., KASS E. H. Effect of artificial fever in increasing susceptibility to bacterial endotoxin. Nature. 1961 Apr 29;190:453–454. doi: 10.1038/190453a0. [DOI] [PubMed] [Google Scholar]
  5. Efrati P., Nir E., Yaari A. Morphological and cytochemical observations on cells of the hemopoietic system of Agama stellio (Linnaeus). A comparative study. Isr J Med Sci. 1970 Jan-Feb;6(1):23–31. [PubMed] [Google Scholar]
  6. Gershon R. K., Askenase P. W., Gershon M. D. Requirement for vasoactive amines for production of delayed-type hypersensitvity skin reactions. J Exp Med. 1975 Sep 1;142(3):732–747. doi: 10.1084/jem.142.3.732. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kanakambika P., Muthukkaruppan V. The immune response to sheep erythrocytes in the lizard Calotes versicolor. J Immunol. 1972 Sep;109(3):415–419. [PubMed] [Google Scholar]
  8. Malawista S. E., Bodel P. T. The dissociation by colchicine of phagocytosis from increased oxygen consumption in human leukocytes. J Clin Invest. 1967 May;46(5):786–796. doi: 10.1172/JCI105579. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Reynolds W. W., Casterlin M. E., Covert J. B. Behavioural fever in teleost fishes. Nature. 1976 Jan 1;259(5538):41–42. doi: 10.1038/259041a0. [DOI] [PubMed] [Google Scholar]
  10. Scholz D., Scharmann W., Blobel H. Leucocidic substances for Aeromonas hydrophila. Zentralbl Bakteriol Orig A. 1974;228(3):312–316. [PubMed] [Google Scholar]
  11. Vaughn L. K., Bernheim H. A., Kluger M. J. Fever in the lizard Dipsosaurus dorsalis. Nature. 1974 Dec 6;252(5483):473–474. doi: 10.1038/252473a0. [DOI] [PubMed] [Google Scholar]
  12. Zigmond S. H., Hirsch J. G. Leukocyte locomotion and chemotaxis. New methods for evaluation, and demonstration of a cell-derived chemotactic factor. J Exp Med. 1973 Feb 1;137(2):387–410. doi: 10.1084/jem.137.2.387. [DOI] [PMC free article] [PubMed] [Google Scholar]

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