Abstract
The cytotoxic effects of 15 dusts have been tested in 2 cell lines. Experimental animal data are available for 11 of the 15 dusts. There is a correlation between the cytotoxic activities of the dusts and the ability to induce mesothelial tumours following intrapleural injection of the dusts. Some preliminary observations on the nature of interaction between the dusts, medium components and the cells are reported. It is suggested that the study of the interactions between cells and dusts in culture may lead to an understanding of the pathogenesis of these dusts in man and animals.
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- Beck E. G. Interaction between fibrous dust and cells in vitro. Ann Anat Pathol (Paris) 1976 Mar-Apr;21(2):227–236. [PubMed] [Google Scholar]
- Bey E., Harington J. S. Cytotoxic effects of some mineral dusts on Syrian hamster peritoneal macrophages. J Exp Med. 1971 May 1;133(5):1149–1169. doi: 10.1084/jem.133.5.1149. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chu E. H., Malling H. V. Mammalian cell genetics. II. Chemical induction of specific locus mutations in Chinese hamster cells in vitro. Proc Natl Acad Sci U S A. 1968 Dec;61(4):1306–1312. doi: 10.1073/pnas.61.4.1306. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Davies P., Allison A. C., Ackerman J., Butterfield A., Williams S. Asbestos induces selective release of lysosomal enzymes from mononuclear phagocytes. Nature. 1974 Oct 4;251(5474):423–425. doi: 10.1038/251423a0. [DOI] [PubMed] [Google Scholar]
- Duncan M. E., Brookes P. The induction of azaguanine-resistant mutants in cultured Chinese hamster cells by reactive derivatives of carcinogenic hydrocarbons. Mutat Res. 1973 Apr;21(2):107–118. [PubMed] [Google Scholar]
- Harington J. S., Allison A. C., Badami D. V. Mineral fibers: chemical, physicochemical, and biological properties. Adv Pharmacol Chemother. 1975;12(0):291–402. doi: 10.1016/s1054-3589(08)60223-9. [DOI] [PubMed] [Google Scholar]
- Harington J. S., Macnab G. M., Miller K., King P. C. Enhancement of haemolytic activity of asbestos by heat-labile factors in fresh serum. Med Lav. 1971 Apr;62(4):171–176. [PubMed] [Google Scholar]
- Harington J. S., Miller K., Macnab G. Hemolysis by asbestos. Environ Res. 1971 Apr;4(2):95–117. doi: 10.1016/0013-9351(71)90038-7. [DOI] [PubMed] [Google Scholar]
- Harington J. S. The biological effects of mineral fibres, especially asbestos, as seen from in vitro and in vivo studies. Ann Anat Pathol (Paris) 1976 Mar-Apr;21(2):155–198. [PubMed] [Google Scholar]
- Lieber M., Smith B., Szakal A., Nelson-Rees W., Todaro G. A continuous tumor-cell line from a human lung carcinoma with properties of type II alveolar epithelial cells. Int J Cancer. 1976 Jan 15;17(1):62–70. doi: 10.1002/ijc.2910170110. [DOI] [PubMed] [Google Scholar]
- Morgan A., Evans J. C., Evans R. J., Hounam R. F., Holmes A., Doyle S. G. Studies on the deposition of inhaled fibrous material in the respiratory tract of the rat and its subsequent clearance using radioactive tracer techniques. Environ Res. 1975 Oct;10(2):196–207. doi: 10.1016/0013-9351(75)90083-3. [DOI] [PubMed] [Google Scholar]
- Morgan A., Lally A. E., Holmes A. Some observations on the distribution of trace metals in chrysotile asbestos. Ann Occup Hyg. 1973 Nov;16(3):231–240. doi: 10.1093/annhyg/16.3.231. [DOI] [PubMed] [Google Scholar]
- Sincock A., Seabright M. Induction of chromosome changes in Chinese hamster cells by exposure to asbestos fibres. Nature. 1975 Sep 4;257(5521):56–58. doi: 10.1038/257056a0. [DOI] [PubMed] [Google Scholar]
- Stanton M. F., Laynard M., Tegeris A., Miller E., May M., Kent E. Carcinogenicity of fibrous glass: pleural response in the rat in relation to fiber dimension. J Natl Cancer Inst. 1977 Mar;58(3):587–603. doi: 10.1093/jnci/58.3.587. [DOI] [PubMed] [Google Scholar]
- Wade M. J., Lipkin L. E., Tucker R. W., Frank A. L. Asbestos cytotoxicity in a long term macrophage-like cell culture. Nature. 1976 Dec 2;264(5585):444–446. doi: 10.1038/264444a0. [DOI] [PubMed] [Google Scholar]
- Wagner J. C., Berry G., Timbrell V. Mesotheliomata in rats after inoculation with asbestos and other materials. Br J Cancer. 1973 Aug;28(2):173–185. doi: 10.1038/bjc.1973.134. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wagner M. M. Pathogenesis of malignant histiocytic lymphoma induced by silica in a colony of specificpathogen-free Wistar rats. J Natl Cancer Inst. 1976 Sep;57(3):509–518. doi: 10.1093/jnci/57.3.509. [DOI] [PubMed] [Google Scholar]