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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1978 Aug;59(4):366–372.

Influence of hydrocortisone on the modulation of the inflammatory response.

G Tolone, L Bonasera, C Tolone
PMCID: PMC2041368  PMID: 81677

Abstract

In vitro hydrocortisone, in pharmacologically attainable concentrations, binds nonspecifically to rat peritoneal mast cells and amplifies the stimulating effects of PGE1 on membrane-bound adenylate cyclase. As a consequence, the intracellular concentration of cyclic AMP in the target cells increases and histamine release is markedly reduced. Deoxycorticosterone, at the same concentrations, has no effect. These findings may in part explain the mechanism of action of anti-inflammatory steroids, possibly related to the modulating effects of E-type prostaglandins.

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Selected References

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  1. Bangham A. D., Standish M. M., Weissmann G. The action of steroids and streptolysin S on the permeability of phospholipid structures to cations. J Mol Biol. 1965 Aug;13(1):253–259. doi: 10.1016/s0022-2836(65)80094-8. [DOI] [PubMed] [Google Scholar]
  2. Baxter J. D., Harris A. W., Tomkins G. M., Cohn M. Glucocorticoid receptors in lymphoma cells in culture: relationship to glucocorticoid killing activity. Science. 1971 Jan 15;171(3967):189–191. doi: 10.1126/science.171.3967.189. [DOI] [PubMed] [Google Scholar]
  3. Bourne H. R., Lichtenstein L. M., Melmon K. L., Henney C. S., Weinstein Y., Shearer G. M. Modulation of inflammation and immunity by cyclic AMP. Science. 1974 Apr 5;184(4132):19–28. doi: 10.1126/science.184.4132.19. [DOI] [PubMed] [Google Scholar]
  4. Fauci A. S., Dale D. C., Balow J. E. Glucocorticosteroid therapy: mechanisms of action and clinical considerations. Ann Intern Med. 1976 Mar;84(3):304–315. doi: 10.7326/0003-4819-84-3-304. [DOI] [PubMed] [Google Scholar]
  5. Hong S. L., Levine L. Inhibition of arachidonic acid release from cells as the biochemical action of anti-inflammatory corticosteroids. Proc Natl Acad Sci U S A. 1976 May;73(5):1730–1734. doi: 10.1073/pnas.73.5.1730. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Jimenez de Asua L., Carr B., Clingan D., Rudland P. Specific glucocorticoid inhibition of growth promoting effects of prostaglandin F2alpha on 3T3 cells. Nature. 1977 Feb 3;265(5593):450–452. doi: 10.1038/265450a0. [DOI] [PubMed] [Google Scholar]
  7. Kantrowitz F., Robinson D. R., McGuire M. B., Levine L. Corticosteroids inhibit prostaglandin production by rheumatiod synovia. Nature. 1975 Dec 25;258(5537):737–739. doi: 10.1038/258737a0. [DOI] [PubMed] [Google Scholar]
  8. Ko S. D., Page R. C., Narayanan A. S. Fibroblast heterogeneity and prostaglandin regulation of subpopulations. Proc Natl Acad Sci U S A. 1977 Aug;74(8):3429–3432. doi: 10.1073/pnas.74.8.3429. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Lewis D. A., Symons A. M., Ancill R. J. Action of anti-inflammatory steroids on the lytic action of phospholipase C and 2,4,6-trinitrobenzene sulphonic acid on lysosomes. Biochem Pharmacol. 1974 Jan 15;23(2):467–470. doi: 10.1016/0006-2952(74)90441-9. [DOI] [PubMed] [Google Scholar]
  10. Lewis G. P., Piper P. J. Inhibition of release of prostaglandins as an explanation of some of the actions of anti-inflammatory corticosteroids. Nature. 1975 Mar 27;254(5498):308–311. doi: 10.1038/254308a0. [DOI] [PubMed] [Google Scholar]
  11. Limbird L. E., Lefkowitz R. J. Resolution of beta-adrenergic receptor binding and adenylate cyclase activity by gel exclusion chromatography. J Biol Chem. 1977 Jan 25;252(2):799–802. [PubMed] [Google Scholar]
  12. Lippman M., Barr R. Glucocorticoid receptors in purified subpopulations of human peripheral blood lymphocytes. J Immunol. 1977 Jun;118(6):1977–1981. [PubMed] [Google Scholar]
  13. Morley J. Prostaglandins and lymphokines in arthritis. Prostaglandins. 1974 Nov 25;8(4):315–326. doi: 10.1016/s0090-6980(74)80096-1. [DOI] [PubMed] [Google Scholar]
  14. Munck A., Brinck-Johnsen T. Specific and nonspecific physicochemical interactions of glucocorticoids and related steroids with rat thymus cells in vitro. J Biol Chem. 1968 Nov 10;243(21):5556–5565. [PubMed] [Google Scholar]
  15. Orly J., Schramm M. Coupling of catecholamine receptor from one cell with adenylate cyclase from another cell by cell fusion. Proc Natl Acad Sci U S A. 1976 Dec;73(12):4410–4414. doi: 10.1073/pnas.73.12.4410. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. PATON W. D. M. Compound 48/80: a potent histamine liberator. Br J Pharmacol Chemother. 1951 Sep;6(3):499–508. doi: 10.1111/j.1476-5381.1951.tb00661.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Persellin R. H., Ku L. C. Effects of steroid hormones on human polymorphonuclear leukocyte lysosomes. J Clin Invest. 1974 Oct;54(4):919–925. doi: 10.1172/JCI107832. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Rudolph S. A., Greengard P., Malawista S. E. Effects of colchicine on cyclic AMP levels in human leukocytes. Proc Natl Acad Sci U S A. 1977 Aug;74(8):3404–3408. doi: 10.1073/pnas.74.8.3404. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Saeed S. A., McDonald-Gibson W. J., Cuthbert J., Copas J. L., Schneider C., Gardiner P. J., Butt N. M., Collier H. O. Endogenous inhibitor of prostaglandin synthetase. Nature. 1977 Nov 3;270(5632):32–36. doi: 10.1038/270032a0. [DOI] [PubMed] [Google Scholar]
  20. Shlatz L., Marinetti G. V. Hormone-calcium interactions with the plasma membrane of rat liver cells. Science. 1972 Apr 14;176(4031):175–177. doi: 10.1126/science.176.4031.175. [DOI] [PubMed] [Google Scholar]
  21. Sullivan T. J., Greene W. C., Parker C. W. Concanavalin A-induced histamine release from normal rat mast cells. J Immunol. 1975 Jul;115(1):278–282. [PubMed] [Google Scholar]
  22. Sullivan T. J., Parker K. L., Stenson W., Parker C. W. Modulation of cyclic AMP in purified rat mast cells. I. Responses to pharmacologic, metabolic, and physical stimuli. J Immunol. 1975 May;114(5):1473–1479. [PubMed] [Google Scholar]
  23. Tashjian A. H., Jr, Voelkel E. F., McDonough J., Levine L. Hydrocortisone inhibits prostaglandin production by mouse fibrosarcoma cells. Nature. 1975 Dec 25;258(5537):739–741. doi: 10.1038/258739a0. [DOI] [PubMed] [Google Scholar]
  24. Tolone G., Bonasera L., Parrinello N. Histamine release from mast cells: role of microtubules. Experientia. 1974 Apr 15;30(4):426–427. doi: 10.1007/BF01921702. [DOI] [PubMed] [Google Scholar]
  25. Tolone G., Bonasera L., Tolone C. Biosynthesis and release of prostaglandins by mast cells. Br J Exp Pathol. 1978 Feb;59(1):105–109. [PMC free article] [PubMed] [Google Scholar]

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