Abstract
The effect of purified human chorionic gonadotropin (HCG) on the migration of inflammatory cells into dacron mesh tissue containing live BCG and implanted under the skin of castrated male and female guinea-pigs was investigated. Cell counts have shown that no significant difference appeared between controls and castrated guinea-pigs given HCG. This work suggests that the inhibiting effect of HCG on the mobility of neutrophil granulocytes is closely related to the presence of both male and female gonads.
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- Baum M. Letter: Variations in leucocyte count during menstrual cycle. Br Med J. 1975 Jul 12;3(5975):102–102. doi: 10.1136/bmj.3.5975.102. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bilder G. E. Effect of endocrine manipulation on graft rejection. Immunol Commun. 1976;5(3):163–179. doi: 10.3109/08820137609044273. [DOI] [PubMed] [Google Scholar]
- Carter J. The effect of progesterone, oestradiol and HCG on cell-mediated immunity in pregnant mice. J Reprod Fertil. 1976 Jan;46(1):211–216. doi: 10.1530/jrf.0.0460211. [DOI] [PubMed] [Google Scholar]
- Clarke F. M., Morton H., Clunie G. J. Detection and separation of two serum factors responsible for depression of lymphocyte activity in pregnancy. Clin Exp Immunol. 1978 May;32(2):318–323. [PMC free article] [PubMed] [Google Scholar]
- Hill C. A., Finn R., Denye V. Depression of cellular immunity in pregnancy due to a serum factor. Br Med J. 1973 Sep 8;3(5879):513–514. doi: 10.1136/bmj.3.5879.513. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kenny J. F., Pangburn P. C., Trail G. Effect of estradiol on immune competence: in vivo and in vitro studies. Infect Immun. 1976 Feb;13(2):448–456. doi: 10.1128/iai.13.2.448-456.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Morton H., Rolfe B., Clunie G. J. An early pregnancy factor detected in human serum by the rosette inhibition test. Lancet. 1977 Feb 19;1(8008):394–397. doi: 10.1016/s0140-6736(77)92605-8. [DOI] [PubMed] [Google Scholar]
- Roubinian J. R., Papoian R., Talal N. Androgenic hormones modulate autoantibody responses and improve survival in murine lupus. J Clin Invest. 1977 Jun;59(6):1066–1070. doi: 10.1172/JCI108729. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Senelar R., Bureau J. P. Inhibitory effect of pregnancy on the migration of the inflammatory cells: a quantitative histological study. Br J Exp Pathol. 1979 Jun;60(3):286–293. [PMC free article] [PubMed] [Google Scholar]
- Siiteri P. K., Febres F., Clemens L. E., Chang R. J., Gondos B., Stites D. Progesterone and maintenance of pregnancy: is progesterone nature's immunosuppressant? Ann N Y Acad Sci. 1977 Mar 11;286:384–397. doi: 10.1111/j.1749-6632.1977.tb29431.x. [DOI] [PubMed] [Google Scholar]
- Sljivić V. S., Clark D. W., Warr G. W. Effects of oestrogens and pregnancy on the distribution of sheep erythrocytes and the antibody response in mice. Clin Exp Immunol. 1975 Apr;20(1):179–186. [PMC free article] [PubMed] [Google Scholar]
- Sljivić V. S., Warr G. W. Activity of the reticuloendothelial system and the antibody response. II. Effect of stilboestrol on the immune response to sheep erythrocytes in the mouse. Br J Exp Pathol. 1973 Feb;54(1):69–78. [PMC free article] [PubMed] [Google Scholar]
- Vernon-Roberts B. The effects of steroid hormones on macrophage activity. Int Rev Cytol. 1969;25:131–159. doi: 10.1016/s0074-7696(08)60202-8. [DOI] [PubMed] [Google Scholar]
- Waltman S. R., Burde R. M., Berrios J. Prevention of corneal homograft rejection by estrogens. Transplantation. 1971 Feb;11(2):194–196. doi: 10.1097/00007890-197102000-00016. [DOI] [PubMed] [Google Scholar]
- Wexler W. M., Kantor F. S. Reticuloendothelial function in pregnancy. Yale J Biol Med. 1966 Feb;38(4):315–322. [PMC free article] [PubMed] [Google Scholar]