Skip to main content
NCBI home page
British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1980 Oct;61(5):479–485.

Restoration by ketoprofen of defective neutrophil granulocyte migration induced in guinea-pigs by plasma from cancer patients.

J P Bureau, R Senelar, D Cupissol
PMCID: PMC2041535  PMID: 7004475

Abstract

The infiltration by inflammatory cells of dacron mesh tissue containing live BCG, implanted under the skin of male and female guinea-pigs treated with normal control and cancer patients' plasmas, was investigated. These cells migrated from the blood vessels to the peri-implant region under the influence of local chemotactic mechanisms generated by the bacilli. Animals given normal or cancer patients' plasmas were unable to produce normal levels of cellular infiltration. This was more markedly reduced with plasma from patients with malignant disease. Cell counts in treated animals have shown significant reduction in while-cell counts but the more marked effect was seen on the polymorphonuclear neutrophil level. Ketoprofen restored normal infiltration responses to animals simultaneously given plasma from cancer patients. These observations further underline the importance of prostaglandins in both inflammation and malignant disease.

Full text

PDF
479

Images in this article

481Fig. 1
on p.481
481Fig. 2
on p.481

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ablin R. J., Bruns G. R., Guinan P. D., Bush I. M. Migration-inhibitory effect of serum from patients with prostatic cancer. Oncology. 1974;30(5):423–428. doi: 10.1159/000224982. [DOI] [PubMed] [Google Scholar]
  2. Alexander P., Eccles S. A., Gauci C. L. The significance of macrophages in human and experimental tumors. Ann N Y Acad Sci. 1976;276:124–133. doi: 10.1111/j.1749-6632.1976.tb41641.x. [DOI] [PubMed] [Google Scholar]
  3. Atkins D., Ibbotson K. J., Hillier K., Hunt N. H., Hammonds J. C., Martin T. J. Secretion of prostaglandins as bone-resorbing agents by renal cortical carcinoma in culture. Br J Cancer. 1977 Nov;36(5):601–607. doi: 10.1038/bjc.1977.237. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. BERG J. W. Inflammation and prognosis in breast cancer; a search for host resistance. Cancer. 1959 Jul-Aug;12(4):714–720. doi: 10.1002/1097-0142(195907/08)12:4<714::aid-cncr2820120414>3.0.co;2-b. [DOI] [PubMed] [Google Scholar]
  5. Bennett A., Del Tacca M. Proceedings: Prostaglandins in human colonic carcinoma. Gut. 1975 May;16(5):409–409. [PubMed] [Google Scholar]
  6. Berenberg J. L., Ward P. A. Chemotactic factor inactivator in normal human serum. J Clin Invest. 1973 May;52(5):1200–1206. doi: 10.1172/JCI107287. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bonta I. L., Parnham M. J. Time-dependent stimulatory and inhibitory effects of prostaglandin E1 on exudative and tissue components of granulomatous inflammation in rats. Br J Pharmacol. 1979 Mar;65(3):465–472. doi: 10.1111/j.1476-5381.1979.tb07852.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Brozna J. P., Ward P. A. Antileukotactic properties of tumor cells. J Clin Invest. 1975 Sep;56(3):616–623. doi: 10.1172/JCI108131. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Brozna J. P., Ward P. A. Suppression of acute and chronic inflammation in tumor-bearing rats. J Clin Invest. 1979 Jul;64(1):302–311. doi: 10.1172/JCI109452. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Cochran A. J., Klein G., Kiessling R., Gunvén P. Migration-inhibiting effect of sera from patients with Burkitt's lymphoma. J Natl Cancer Inst. 1973 Nov;51(5):1431–1436. doi: 10.1093/jnci/51.5.1431. [DOI] [PubMed] [Google Scholar]
  11. Cohen S., Fisher B., Yoshida T., Bettigole R. E. Serum migration-inhibitory activity in patients with lymphoproliferative diseases. N Engl J Med. 1974 Apr 18;290(16):882–886. doi: 10.1056/NEJM197404182901605. [DOI] [PubMed] [Google Scholar]
  12. Currie G. A., Basham C. Activated macrophages release a factor which lyses malignant cells but not normal cells. J Exp Med. 1975 Dec 1;142(6):1600–1605. doi: 10.1084/jem.142.6.1600. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Diaz-Perez J. L., Goldyne M. E., Winkelmann R. K. Prostaglandins and chemotaxis: enhancement of polymorphonuclear leukocyte chemotaxis by prostaglandin F2alpha. J Invest Dermatol. 1976 Mar;66(3):149–152. doi: 10.1111/1523-1747.ep12481893. [DOI] [PubMed] [Google Scholar]
  14. Dvorak A. M., Connell A. B., Proppe K., Dvorak H. F. Immunologic rejection of mammary adenocarcinoma (TA3-St) in C57BL/6 mice: participation of neutrophils and activated macrophages with fibrin formation. J Immunol. 1978 Apr;120(4):1240–1248. [PubMed] [Google Scholar]
  15. Eilber F. R., Morton D. L. Impaired immunologic reactivity and recurrence following cancer surgery. Cancer. 1970 Feb;25(2):362–367. doi: 10.1002/1097-0142(197002)25:2<362::aid-cncr2820250213>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  16. Estensen R. D., Hill H. R., Quie P. G., Gogan N., Goldberg N. D. Cyclic GMP and cell movement. Nature. 1973 Oct 26;245(5426):458–460. doi: 10.1038/245458a0. [DOI] [PubMed] [Google Scholar]
  17. Fauve R. M., Hevin B., Jacob H., Gaillard J. A., Jacob F. Antiinflammatory effects of murine malignant cells. Proc Natl Acad Sci U S A. 1974 Oct;71(10):4052–4056. doi: 10.1073/pnas.71.10.4052. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Gallin J. I., Sandler J. A., Clyman R. I., Manganiello V. C., Vaughan M. Agents that increase cyclic AMP inhibit accumulation of cGMP and depress human monocyte locomotion. J Immunol. 1978 Feb;120(2):492–496. [PubMed] [Google Scholar]
  19. Goetzl E. J., Gorman R. R. Chemotactic and chemokinetic stimulation of human eosinophil and neutrophil polymorphonuclear leukocytes by 12-L-hydroxy-5,8,10-heptadecatrienoic acid (HHT). J Immunol. 1978 Feb;120(2):526–531. [PubMed] [Google Scholar]
  20. Grinwich K. D., Plescia O. J. Tumor-mediated immunosuppression: prevention by inhibitors of prostaglandin synthesis. Prostaglandins. 1977;14(6):1175–1182. doi: 10.1016/0090-6980(77)90294-5. [DOI] [PubMed] [Google Scholar]
  21. Jaffe B. M. Prostaglandins and cancer: an update. Prostaglandins. 1974 Jun 25;6(6):453–461. doi: 10.1016/s0090-6980(74)80055-9. [DOI] [PubMed] [Google Scholar]
  22. Johnson M. W., Maibach H. I., Salmon S. E. Skin reactivity in patients with cancer. Impaired delayed hypersensitivity or faulty inflammatory response? N Engl J Med. 1971 Jun 3;284(22):1255–1257. doi: 10.1056/NEJM197106032842210. [DOI] [PubMed] [Google Scholar]
  23. LAMB D., PILNEY F., KELLY W. D., GOOD R. A. A comparative study of the incidence of anergy in patients with carcinoma, leukemia, hodgkin's disease and other lymphomas. J Immunol. 1962 Oct;89:555–558. [PubMed] [Google Scholar]
  24. Levine L., Ohuchi K. Stimulation by carcinogens and promoters of prostaglandin production by dog kidney (MDCK) cells in culture. Cancer Res. 1978 Nov;38(11 Pt 2):4142–4146. [PubMed] [Google Scholar]
  25. MAHONEY M. J., LEIGHTON J. The inflammatory response to a foreign body within transplantable tumors. Cancer Res. 1962 Apr;22:334–338. [PubMed] [Google Scholar]
  26. Maderazo E. G., Anton T. F., Ward P. A. Serum-associated inhibition of leukotaxis in humans with cancer. Clin Immunol Immunopathol. 1978 Feb;9(2):166–176. doi: 10.1016/0090-1229(78)90068-5. [DOI] [PubMed] [Google Scholar]
  27. McClatchey W., Snyderman R. Prostaglandins and inflammation: enhancement of monocyte chemotactic responsiveness by prostaglandin E2. Prostaglandins. 1976 Sep;12(3):415–426. doi: 10.1016/0090-6980(76)90022-8. [DOI] [PubMed] [Google Scholar]
  28. Parker C. W., Baumann M. L., Huber M. G. Alterations in cyclic AMP metabolism in human bronchial asthma. II. Leukocyte and lymphocyte responses to prostaglandins. J Clin Invest. 1973 Jun;52(6):1336–1341. doi: 10.1172/JCI107305. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Perper R. J., Sanda M., Stecher V. J., Oronsky A. L. Physiologic and pharmacologic alterations of rat leukocyte chemotaxis (Cx) in vivo. Ann N Y Acad Sci. 1975 Jun 13;256:190–209. doi: 10.1111/j.1749-6632.1975.tb36047.x. [DOI] [PubMed] [Google Scholar]
  30. Pickaver A. H., Ratcliffe N. A., Williams A. E., Smith H. Cytotoxic effects of peritoneal neutrophils on a syngeneic rat tumour. Nat New Biol. 1972 Feb 9;235(58):186–187. doi: 10.1038/newbio235186a0. [DOI] [PubMed] [Google Scholar]
  31. Pike M. C., Snyderman R. Depression of macrophage function by a factor produced by neoplasms: a merchanism for abrogation of immune surveillance. J Immunol. 1976 Oct;117(4):1243–1249. [PubMed] [Google Scholar]
  32. Plescia O. J., Grinwich K., Plescia A. M. Subversive activity of syngeneic tumor cells as an escape mechanism from immune surveillance and the role of prostaglandins. Ann N Y Acad Sci. 1976;276:455–465. doi: 10.1111/j.1749-6632.1976.tb41670.x. [DOI] [PubMed] [Google Scholar]
  33. Rabson A. R., Anderson R., Glover A., Lomnitzer R. Inhibitory effect of prostaglandin A1 on neutrophil motility. Br J Exp Pathol. 1978 Jun;59(3):298–304. [PMC free article] [PubMed] [Google Scholar]
  34. Rivkin I., Rosenblatt J., Becker E. L. The role of cyclic AMP in the chemotactic responsiveness and spontaneous motility of rabbit peritoneal neutrophils. The inhibition of neutrophil movement and the elevation of cyclic AMP levels by catecholamines, prostaglandins, theophylline and cholera toxin. J Immunol. 1975 Oct;115(4):1126–1134. [PubMed] [Google Scholar]
  35. Senelar R., Bureau J. P. In vivo effect of human chorionic gonadotropin on the migration of inflammatory cells in intact or castrated male and female guinea-pigs. A quantitative histological study. I. Study of intact male and female guinea-pigs. Br J Exp Pathol. 1979 Oct;60(5):483–488. [PMC free article] [PubMed] [Google Scholar]
  36. Senelar R., Bureau J. P. In vivo effect of human chorionic gonadotropin on the migration of inflammatory cells in intact or castrated male and female guinea-pigs: a quantitative histological study. II. Study of castrated males and females. Br J Exp Pathol. 1979 Oct;60(5):489–492. [PMC free article] [PubMed] [Google Scholar]
  37. Senelar R., Bureau J. P. Inhibitory effect of pregnancy on the migration of the inflammatory cells: a quantitative histological study. Br J Exp Pathol. 1979 Jun;60(3):286–293. [PMC free article] [PubMed] [Google Scholar]
  38. Slauson D. O., Dahlstrom M. A. The pulmonary inflammatory response. Cellular events in experimental pulmonary arterial hypersensitivity disease. Am J Pathol. 1975 Apr;79(1):119–130. [PMC free article] [PubMed] [Google Scholar]
  39. Snyderman R., Phillips J. K., Mergenhagen S. E. Biological activity of complement in vivo. Role of C5 in the accumulation of polymorphonuclear leukocytes in inflammatory exudates. J Exp Med. 1971 Nov 1;134(5):1131–1143. doi: 10.1084/jem.134.5.1131. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Spector W. G., Walters M. N., Willoughby D. A. The origin of the mononuclear cells in inflammatory exudates induced by fibrinogen. J Pathol Bacteriol. 1965 Jul;90(1):181–192. doi: 10.1002/path.1700900119. [DOI] [PubMed] [Google Scholar]
  41. Till G., Ward P. A. Two distinct chemotactic factor inactivators in human serum. J Immunol. 1975 Feb;114(2 Pt 2):843–847. [PubMed] [Google Scholar]
  42. Van Epps D. E., Palmer D. L., Williams R. C., Jr Characterization of serum inhibitors of neutrophil chemotaxis associated with anergy. J Immunol. 1974 Jul;113(1):189–200. [PubMed] [Google Scholar]
  43. Vane J. R. The mode of action of aspirin and similar compounds. J Allergy Clin Immunol. 1976 Dec;58(6):691–712. doi: 10.1016/0091-6749(76)90181-0. [DOI] [PubMed] [Google Scholar]
  44. Ward P. A., Berenberg J. L. Defective regulation of inflammatory mediators in Hodgkin's disease. Supernormal levels of chemotactic-factor inactivator. N Engl J Med. 1974 Jan 10;290(2):76–80. doi: 10.1056/NEJM197401102900203. [DOI] [PubMed] [Google Scholar]
  45. Ward P. A. Complement-dependent phlogistic factors in rheumatoid synovial fluids. Ann N Y Acad Sci. 1975 Jun 13;256:169–176. doi: 10.1111/j.1749-6632.1975.tb36045.x. [DOI] [PubMed] [Google Scholar]

Articles from British journal of experimental pathology are provided here courtesy of Wiley

RESOURCES