Abstract
Organ cultures of human and guinea-pig genital mucosa were inoculated with Neisseria gonorrhoeae, and the association of the bacteria with the epithelial surface of each tissue was studied by light microscopy and by scanning electron microscopy. Gonococci attached to the mucosa of human fallopian tube, adhering specifically to the surface of non-ciliated epithelial cells. In contrast, gonococci rarely attached to the mucosal surface of guinea-pig uterine horn, vagina or bladder, although organisms were occasionally seen associated with the submucosal tissue in areas where the epithelium had sloughed, and in extracellular mucus secretions. There is no evidence from this study that gonococci adhere to guinea-pig tissue in a manner analogous to that seen with human genital tissue.
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- Chandler F. W., Jr, Kraus S. J. Animal model of human disease. Gonorrhea. Am J Pathol. 1976 Feb;82(2):437–440. [PMC free article] [PubMed] [Google Scholar]
- Johnson A. P., Taylor-Robinson D., McGee Z. A. Species specificity of attachment and damage to oviduct mucosa by Neisseria gonorrhoeae. Infect Immun. 1977 Dec;18(3):833–839. doi: 10.1128/iai.18.3.833-839.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KELLOGG D. S., Jr, PEACOCK W. L., Jr, DEACON W. E., BROWN L., PIRKLE D. I. NEISSERIA GONORRHOEAE. I. VIRULENCE GENETICALLY LINKED TO CLONAL VARIATION. J Bacteriol. 1963 Jun;85:1274–1279. doi: 10.1128/jb.85.6.1274-1279.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McGee Z. A., Johnson A. P., Taylor-Robinson D. Human fallopian tubes in organ culture: preparation, maintenance, and quantitation of damage by pathogenic microorganisms. Infect Immun. 1976 Feb;13(2):608–618. doi: 10.1128/iai.13.2.608-618.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sowter C., McGEE Z. A. Evaluation of a new technique for the demonstration of gonococci and other micro-organisms in host cells. J Clin Pathol. 1976 May;29(5):433–437. doi: 10.1136/jcp.29.5.433. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Taylor-Robinson D., Whytock S., Green C. J., Carney F. E., Jr Effect of Neisseria gonorrhoeae on human and rabbit oviducts. Br J Vener Dis. 1974 Aug;50(4):279–288. doi: 10.1136/sti.50.4.279. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tebbutt G. M., Veale D. R., Hutchison J. G., Smith H. The adherence of pilate and non-pilate strains of Neisseria gonorrhoeae to human and guinea-pig epithelial tissues. J Med Microbiol. 1976 Aug;9(3):263–273. doi: 10.1099/00222615-9-3-263. [DOI] [PubMed] [Google Scholar]
- Thayer J. D., Martin J. E., Jr Improved medium selective for cultivation of N. gonorrhoeae and N. meningitidis. Public Health Rep. 1966 Jun;81(6):559–562. [PMC free article] [PubMed] [Google Scholar]
- Ward M. E., Watt P. J. Adherence of Neisseria gonorrhoeae to urethral mucosal cells: an electron-microscopic study of human gonorrhea. J Infect Dis. 1972 Dec;126(6):601–605. doi: 10.1093/infdis/126.6.601. [DOI] [PubMed] [Google Scholar]
- Ward M. E., Watt P. J., Robertson J. N. The human fallopian tube: a laboratory model for gonococcal infection. J Infect Dis. 1974 Jun;129(6):650–659. doi: 10.1093/infdis/129.6.650. [DOI] [PubMed] [Google Scholar]