Skip to main content
PMC home page
British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1980 Feb;61(1):16–21.

Metabolic sequelae of experimental leptospirosis in grivet monkeys.

P Hambleton, A Baskerville, R B Marshall, P W Harris-Smith, G D Adams
PMCID: PMC2041547  PMID: 6769455

Abstract

Leptospira interrogans serovars balcanica and tarassovi both induced mild subclinical infections in grivet monkeys. The activities in serum of lactate dehydrogenase, alpha-hydroxybutyrate dehydrogenase, aspartate aminotransferase, alanine aminotransferase and creatine phosphokinase and the level of alpha 1-antichymotrypsin increased in a few days after infection. Concomitant decreases in serum iron levels were observed in some cases. These changes occurred in the absence of any observable clinical signs though there were histopathological lesions in some organs. No haematological changes or alterations in other sreum components were detected.

Full text

PDF
16

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AREAN V. M. Studies on the pathogenesis of leptospirosis. II. A clinicopathologic evaluation of hepatic and renal function in experimental leptospiral infections. Lab Invest. 1962 Apr;11:273–288. [PubMed] [Google Scholar]
  2. Berendt R. F., Long G. G., Abeles F. B., Canonico P. G., Elwell M. R., Powanda M. C. Pathogenesis of respiratory Klebsiella pneumoniae infection in rats: bacteriological and histological findings and metabolic alterations. Infect Immun. 1977 Feb;15(2):586–593. doi: 10.1128/iai.15.2.586-593.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Canonico P. G., Powanda M. C., Cockerell G. L., Moe J. B. Relationship of serum beta-glucuronidase and lysozyme to pathogenesis of tularemia in immune and nonimmune rats. Infect Immun. 1975 Jul;12(1):42–47. doi: 10.1128/iai.12.1.42-47.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Eddington C. L., Upchurch H. F., Kampschmidt R. F. Effect of extracts from rabbit leukocytes on levels of acute phase globulins in rat serum. Proc Soc Exp Biol Med. 1971 Jan;136(1):159–164. doi: 10.3181/00379727-136-35217. [DOI] [PubMed] [Google Scholar]
  5. Hambleton P., Baskerville A., Harris-Smith P. W., Bailey N. E. Changes in whole blood and serum components of grivet monkeys with experimental respiratory Francisella tularensis infection. Br J Exp Pathol. 1978 Dec;59(6):630–639. [PMC free article] [PubMed] [Google Scholar]
  6. Hambleton P., Harris-Smith P. W., Bailey N. E., Strange R. E. Changes in whole blood and serum components during Francisella tularensis and rabbit pox infections of rabbits. Br J Exp Pathol. 1977 Dec;58(6):644–652. [PMC free article] [PubMed] [Google Scholar]
  7. Hambleton P., Harris-Smith P. W., Baskerville A., Bailey N. E., Pavey K. J. Normal values for some whole blood and serum components of grivet monkeys (Cercopithecus aethiops). Lab Anim. 1979 Apr;13(2):87–91. doi: 10.1258/002367779780943585. [DOI] [PubMed] [Google Scholar]
  8. Keenan K. P., Alexander A. D., Mongomery C. A., Jr Pathogenesis of experimental Leptospira interrogans, serovar bataviae, infection in the dog: microbiological, clinical, hematologic, and biochemical studies. Am J Vet Res. 1978 Mar;39(3):449–454. [PubMed] [Google Scholar]
  9. LOW D. G., HIATT C. W., GLEISER C. A., BERGMAN E. N. Experimental canine leptospirosis. I. Leptospira icterohemorrhagiae infections in immature dogs. J Infect Dis. 1956 May-Jun;98(3):249–259. doi: 10.1093/infdis/98.3.249. [DOI] [PubMed] [Google Scholar]
  10. Marshall R. B. Ultrastructural changes in renal tubules of sheep following experimental infection with Leptospira interrogans serotype pomona. J Med Microbiol. 1974 Nov;7(4):505–508. doi: 10.1099/00222615-7-4-505. [DOI] [PubMed] [Google Scholar]
  11. Osserman E. F., Lawlor D. P. Serum and urinary lysozyme (muramidase) in monocytic and monomyelocytic leukemia. J Exp Med. 1966 Nov 1;124(5):921–952. doi: 10.1084/jem.124.5.921. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Powanda M. C. Changes in body balances of nitrogen and other key nutrients: description and underlying mechanisms. Am J Clin Nutr. 1977 Aug;30(8):1254–1268. doi: 10.1093/ajcn/30.8.1254. [DOI] [PubMed] [Google Scholar]
  13. Powanda M. C., Cockerell G. L., Moe J. B., Abeles F. B., Pekarek R. S., Canonico P. G. Induced metabolic sequelae of tularemia in the rat: correlation with tissue damage. Am J Physiol. 1975 Aug;229(2):479–483. doi: 10.1152/ajplegacy.1975.229.2.479. [DOI] [PubMed] [Google Scholar]
  14. Powanda M. C., Kenyon R. H., Moe J. B. Alterations in plasma copper, zinc, amino acids, and seromucoid during Rocky Moutain spotted fever in guinea pigs. Proc Soc Exp Biol Med. 1976 Apr;151(4):804–807. doi: 10.3181/00379727-151-39311. [DOI] [PubMed] [Google Scholar]
  15. Rose C. I., Henderson A. R. Reaction-rate assay of serum sorbitol dehydrogenase activity of 37 degrees C. Clin Chem. 1975 Oct;21(11):1619–1626. [PubMed] [Google Scholar]
  16. Taylor P. L., Hanson L. E., Simon J. Serologic, pathologic, and immunologic features of experimentally induced leptospiral nephritis in dogs. Am J Vet Res. 1970 Jun;31(6):1033–1049. [PubMed] [Google Scholar]
  17. Wannemacher R. W., Jr, DuPont H. L., Pekarek R. S., Powanda M. C., Schwartz A., Hornick R. B., Beisel W. R. An endogenous mediator of depression of amino acids and trace metals in serum during typhoid fever. J Infect Dis. 1972 Jul;126(1):77–86. doi: 10.1093/infdis/126.1.77. [DOI] [PubMed] [Google Scholar]
  18. Wannemacher R. W., Jr, Klainer A. S., Dinterman R. E., Beisel W. R. The significance and mechanism of an increased serum phenylalanine-tyrosine ratio during infection. Am J Clin Nutr. 1976 Sep;29(9):997–1006. doi: 10.1093/ajcn/29.9.997. [DOI] [PubMed] [Google Scholar]
  19. Wannemacher R. W., Jr, Pekarek R. S., Klainer A. S., Bartelloni P. J., Dupont H. L., Hornick R. B., Beisel W. R. Detection of a leukocytic endogenous mediator-like mediator of serum amino acid and zinc depression during various infectious illnesses. Infect Immun. 1975 Apr;11(4):873–875. doi: 10.1128/iai.11.4.873-875.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Wannemacher R. W., Jr, Pekarek R. W., Bartelloni P. J., Vollmer R. T., Beisel W. R. Changes in individual plasma amino acids following experimentally induced and fly fever virus infection. Metabolism. 1972 Jan;21(1):67–76. doi: 10.1016/0026-0495(72)90021-2. [DOI] [PubMed] [Google Scholar]

Articles from British journal of experimental pathology are provided here courtesy of Wiley

RESOURCES