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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1980 Dec;61(6):617–623.

A new look at reticuloendothelial blockade.

J W Bradfield
PMCID: PMC2041617  PMID: 6161632

Abstract

The characteristics of so-called reticuloendothelial blockade have been reinvestigated in mice using organ uptake, rather than blood clearance, as the main method of assessment. Blockade was induced by using i.v. dextran sulphate. I.v. 51Cr-labelled sheep red blood cells were used as test particles. Although clearance of colloid from the bloodstream induced prolongation of reticuloendothelial clearance of a subsequent dose of test particles, this was solely due to depression of hepatic phagocytosis and the splenic and bone-marrow clearance remained unimpaired. Because of this highly selective action of i.v. blockading colloid, and because testing via the i.v. route can only provide information about macrophages which line blood channels, the expression reticuloendothelial blockade is entirely inappropriate to describe these phenomena. Unexpectedly, the effects could be quantitated using a wide range of doses of this test particle and saturating doses were not required.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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