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British Journal of Experimental Pathology logoLink to British Journal of Experimental Pathology
. 1981 Dec;62(6):583–590.

Intravascular coagulation in mice by the compact-colony-forming active substance (CCFAS) extracted from a strain of Staphylococcus aureus.

K Yoshida, T Ohtomo, Y Ichiman, S Narikawa, K Oikawa
PMCID: PMC2041728  PMID: 7034764

Abstract

The compact-colony-forming active substance (CCFAS) extracted from a Staphylococcus aureus strain was capable of killing mice only when Staph. aureus, Staph. epidermidis or Escherichia coli was injected i.v. before the injection of CCFAS. In the mice killed 30 min after treatment with heat-killed Staph. aureus and CCFAS, remarkable congestion of the lung and thrombus-like lesions in the kidney were observed. In the mice killed 6 h after injection with CCFAS and living Staph. aureus congestion and inflammatory-cell filtration were found in the liver, especially within the Glisson's capsule. However, when mice were killed 30 days after treatment with CCFAS and Staph. aureus, fibrin and hyalin thrombi were observed most frequently in the renal glomeruli but also in the liver and lung.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. FINLAND M. Treatment of pneumonia and other serious infections. N Engl J Med. 1960 Aug 4;263:207–221. doi: 10.1056/NEJM196008042630501. [DOI] [PubMed] [Google Scholar]
  2. GODAL H. C. The interaction of protamine with human fibrinogen and the significance of this interaction for the coagulation of fibrinogen. Scand J Clin Lab Invest. 1960;12(4):433–445. doi: 10.3109/00365516009065408. [DOI] [PubMed] [Google Scholar]
  3. HENRY R. L. Methods for inducing experimental thrombosis. Angiology. 1962 Dec;13:554–577. doi: 10.1177/000331976201301203. [DOI] [PubMed] [Google Scholar]
  4. Hawiger J., Hawiger A., Koenig M. G. Staphylococcal clumping and fibrinogen and fibrin degradation products in inflammatory exudate. Proc Soc Exp Biol Med. 1971 Jan;136(1):132–136. doi: 10.3181/00379727-136-35211. [DOI] [PubMed] [Google Scholar]
  5. Hawiger J., Steckley S., Hammond D., Cheng C., Timmons S., Glick A. D., Des Prez R. M. Staphylococci-induced human platelet injury mediated by protein A and immunoglobulin G Fc fragment receptor. J Clin Invest. 1979 Oct;64(4):931–937. doi: 10.1172/JCI109559. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. JELJASZEWICZ J., NIEWIAROWSKI S., POPLAWSKI A., PROKOPOWICZ J., WOROWSKI K. INTRAVASCULAR COAGULATION AND FIBRINOLYSIS BY STAPHYLOCOAGULASE. COMPARISON WITH THROMBIN. Thromb Diath Haemorrh. 1965 Jun 15;13:457–469. [PubMed] [Google Scholar]
  7. Mojovic B., Mojovic N., Tager M., Drummond M. C. Staphylocoagulase as a hemostatic agent. Yale J Biol Med. 1969 Aug;42(1):11–20. [PMC free article] [PubMed] [Google Scholar]
  8. Ohtomo T., Yoshida K., Hasegawa A. Comparison of the reactions of the compact-colony forming active substance (CCFAS) to the clumping-factor reaction in a strain of Staphylococcus aureus with animal plasma. Med Microbiol Immunol. 1980;168(4):261–265. doi: 10.1007/BF02121809. [DOI] [PubMed] [Google Scholar]
  9. Rampling M. W. Interactions between dextran, fibrinogen and plasma membranes. Biochem Pharmacol. 1976 Apr 1;25(7):751–752. doi: 10.1016/0006-2952(76)90140-4. [DOI] [PubMed] [Google Scholar]
  10. Rytel M. W., Dee T. H., Ferstenfeld J. E., Hensley G. T. Possible pathogenetic role of capsular antigens in fulminant pneumococcal disease with disseminated intravascular coagulation (DIC). Am J Med. 1974 Dec;57(6):889–896. doi: 10.1016/0002-9343(74)90166-1. [DOI] [PubMed] [Google Scholar]
  11. SMITH D. D., JOHNSTONE J. M. Staphylo-coagulase activity in vivo. Br J Exp Pathol. 1958 Apr;39(2):165–170. [PMC free article] [PubMed] [Google Scholar]
  12. Stewart G. J., Niewiarowski S. Nonenzymatic polymerization of fibrinogen by protamine sulfate. An electron microscope study. Biochim Biophys Acta. 1969 Dec 23;194(2):462–469. doi: 10.1016/0005-2795(69)90106-8. [DOI] [PubMed] [Google Scholar]
  13. Ulevitch R. J., Cochrane C. G., Henson P. M., Morrison D. C., Doe W. F. Mediation systems in bacterial lipopolysaccharide-induced hypotension and disseminated intravascular coagulation. I. The role of complement. J Exp Med. 1975 Dec 1;142(6):1570–1590. doi: 10.1084/jem.142.6.1570. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Yoshida K., Ohtomo T., Minegishi Y. Mechanism of compact-colony formation by strains of Staphylococcus aureus in serum soft agar. J Gen Microbiol. 1977 Jan;98(1):67–75. doi: 10.1099/00221287-98-1-67. [DOI] [PubMed] [Google Scholar]
  15. Yoshida K., Ohtomo T., Usui Y. Interaction of an alkali stable polysaccharide from cell surface of Staphylococci with human fibrinogen. Experientia. 1978 Jul 15;34(7):885–886. doi: 10.1007/BF01939683. [DOI] [PubMed] [Google Scholar]
  16. Yoshida K., Otomo T., Minegishi Y. Extraction of a compact colony-forming active substance from Staphylococcus aureus strains. Jpn J Microbiol. 1975 Feb;19(1):75–76. doi: 10.1111/j.1348-0421.1975.tb00851.x. [DOI] [PubMed] [Google Scholar]
  17. Yoshida K., Takahashi M., Haga K., Kono E., Kushiro H., Ito S. Comparison of three blood-clotting substances in Staphylococcus aureus strains. J Clin Microbiol. 1980 Mar;11(3):293–294. doi: 10.1128/jcm.11.3.293-294.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]

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