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British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1996 Jun;41(6):613–615. doi: 10.1046/j.1365-2125.1996.35220.x

Bioavailability of the antiemetic metopimazine given as a microenema

JØRN HERRSTEDT 1, MORTEN JØRGENSEN 1, HELLE RIIS ANGELO 2, MARGRETHE RØMER RASSING 3, JØRN MØLLER-SONNERGAARD 3, PER DOMBERNOWSKY 1
PMCID: PMC2042615  PMID: 8799530

Abstract

The absorption of the antiemetic metopimazine (MPZ) given as a single dose of (a) 40 mg microenema, (b) 40 mg orally and (c) 10 mg as a 60 min i.v. continuous infusion was investigated in six healthy volunteers. Blood samples were drawn and the serum concentrations of MPZ and its acid metabolite were measured. The bioavailability of MPZ given orally and as enemas was 22.3 and 19.5% respectively. Partial avoidance of hepatic first pass metabolism was seen with the enemas, which in contrast to suppositories, seems to represent a reliable form of rectal administration.

Keywords: antiemetics, metopimazine, bioavailability, enemas

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