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. 2007 Jul 30;151(7):1137. doi: 10.1038/sj.bjp.0707378

Species-specific in vitro pharmacological effects of the cannabinoid receptor 2 (CB2) selective ligand AM1241 and its resolved enantiomers

B Bingham, P G Jones, A J Uveges, S Kotnis, P Lu, V A Smith, S-C Sun, L Resnick, M Chlenov, Y He, B W Strassle, T A Cummons, M J Piesla, J E Harrison, G T Whiteside, J D Kennedy
PMCID: PMC2042942

Correction to: British Journal of Pharmacology (2007) 151, 1061–1070. doi: 10.1038/sj.bjp.0707303

Since the online publication of the above paper, the authors have noticed an error in the labelling of Figure 4b. The corrected figure is shown below.

Figure 4.

Figure 4

Effects of R,S-AM1241 and its enantiomers, R-AM1241 and S-AM1241, on visceral pain and thermal hyperalgesia associated with chemical irritants. (a) Male CD-1 mice (25–30 g; n=10 per group) were pretreated with vehicle or compound (s.c.) 30 min before PPQ administration and tested 10 min post-administration. Data (mean±s.e.m.) are expressed as percent blockade relative to vehicle-treated mice. (b) Male SD rats (220–250 g; n=8 per group) received an intraplantar injection of 50 μl of saline or 2% carrageenan into the hindpaw, followed 2.5 h later by i.p. administration of vehicle, R,S-AM1241, R-AM1241 or S-AM1241. Data (mean±s.e.m.) are expressed as percent reversal relative to vehicle-treated rats. (c) Male SD rats (220–250 g; n=10 per group) received an intraplantar injection of 50 μl of saline or 2% carrageenan into the hindpaw, followed 2.5 h later by i.p. administration of either vehicle or 10 mg kg−1 S-AM1241 and either vehicle or 1 mg kg−1 AM630. Data (mean±s.e.m.) are expressed as paw withdrawal latencies; pre-carrageenan baseline data not shown. I.p., intraperitoneal; SD rat, Sprague–Dawley rat.


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