Skip to main content
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1979 Sep;67(1):103–107.

Muscimol antagonism of morphine analgesia in rats.

P Mantegazza, R Tammiso, L Vicentini, F Zambotti, N Zonta
PMCID: PMC2043611  PMID: 497517

Abstract

1 Muscimol, a gamma-aminobutyric acid (GABA) receptor agonist, when injected intraventricularly antagonizes the antinociceptive effect of morphine given either subcutaneously or intraventricularly. The antagonistic effect of muscimol on morphine analgesia appears to be linearly related. 2 This finding provides support for the view that a GABA-ergic system is involved in morphine analgesia.

Full text

PDF
103

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Altaffer F. B., Verster F. S., Hall S., Long C. J., D'encarnacao P. A simple and inexpensive cannula technique for chemical stimulation of the brain. Physiol Behav. 1970 Jan;5(1):119–121. doi: 10.1016/0031-9384(70)90022-3. [DOI] [PubMed] [Google Scholar]
  2. Biggio G., Bella D. D., Frigeni V., Guidotti A. Potentiation of morphine analgesia by muscimol. Neuropharmacology. 1977 Feb;16(2):149–150. doi: 10.1016/0028-3908(77)90063-6. [DOI] [PubMed] [Google Scholar]
  3. Christensen A. V., Arnt J., Scheel-Krüger J. Muscimol antagonizes morphine hypermotility without potentiation of analgesia. Eur J Pharmacol. 1978 Apr 15;48(4):459–462. doi: 10.1016/0014-2999(78)90176-0. [DOI] [PubMed] [Google Scholar]
  4. Chéramy A., Nieoullon A., Glowinski J. Gabaergic processes involved in the control of dopamine release from nigrostriatal dopaminergic neurons in the cat. Eur J Pharmacol. 1978 Apr 1;48(3):281–295. doi: 10.1016/0014-2999(78)90087-0. [DOI] [PubMed] [Google Scholar]
  5. Gottesfeld Z., Kelly J. S., Renaud L. P. The in vivo neuropharmacology of amino-oxyacetic acid in the cerebral cortex of the cat. Brain Res. 1972 Jul 20;42(2):319–335. doi: 10.1016/0006-8993(72)90534-3. [DOI] [PubMed] [Google Scholar]
  6. Grofová I., Ottersen O. P., Rinvik E. Mesencephalic and diencephalic afferents to the superior colliculus and periaqueductal gray substance demonstrated by retrograde axonal transport of horseradish peroxidase in the cat. Brain Res. 1978 May 12;146(2):205–220. doi: 10.1016/0006-8993(78)90969-1. [DOI] [PubMed] [Google Scholar]
  7. Ho I. K., Loh H. H., Way E. L. Pharmacological manipulation of gamma-aminobutyric acid (GABA) in morphine analgesia, tolerance and physical dependence. Life Sci. 1976 May 15;18(10):1111–1123. doi: 10.1016/0024-3205(76)90146-6. [DOI] [PubMed] [Google Scholar]
  8. Kuriyama K., Yoneda Y. Morphine induced alterations of gamma-aminobutyric acid and taurine contents and L-glutamate decarboxylase activity in rat spinal cord and thalamus: possible correlates with analgesic action of morphine. Brain Res. 1978 Jun 9;148(1):163–179. doi: 10.1016/0006-8993(78)90386-4. [DOI] [PubMed] [Google Scholar]
  9. Snodgrass S. R. Use of 3H-muscimol for GABA receptor studies. Nature. 1978 Jun 1;273(5661):392–394. doi: 10.1038/273392a0. [DOI] [PubMed] [Google Scholar]
  10. Tulunay F. C., Sparber S. B., Takemori A. E. The effect of dopaminergic stimulation and blockade on the nociceptive and antinociceptive responses of mice. Eur J Pharmacol. 1975 Aug;33(1):65–70. doi: 10.1016/0014-2999(75)90139-9. [DOI] [PubMed] [Google Scholar]
  11. VanderWende C., Spoerlein M. T. Role of dopaminergic receptors in morphine analgesia and tolerance. Res Commun Chem Pathol Pharmacol. 1973 Jan;5(1):35–43. [PubMed] [Google Scholar]
  12. Walters J. R., Lakoski J. M. Effect of muscimol on single unit activity of substantia nigra dopamine neurons. Eur J Pharmacol. 1978 Feb 15;47(4):469–471. doi: 10.1016/0014-2999(78)90130-9. [DOI] [PubMed] [Google Scholar]
  13. Yaksh T. L., Plant R. L., Rudy T. A. Studies on the antagonism by raphe lesions of the antinociceptive action of systemic morphine. Eur J Pharmacol. 1977 Feb 21;41(4):399–408. doi: 10.1016/0014-2999(77)90260-6. [DOI] [PubMed] [Google Scholar]
  14. Yaksh T. L., Yeung J. C., Rudy T. A. Systematic examination in the rat of brain sites sensitive to the direct application of morphine: observation of differential effects within the periaqueductal gray. Brain Res. 1976 Sep 10;114(1):83–103. doi: 10.1016/0006-8993(76)91009-x. [DOI] [PubMed] [Google Scholar]
  15. Yoneda Y., Takashima S., Kuriyama K. Possible involvement of GABA in morphine analgesia. Biochem Pharmacol. 1976 Dec 1;25(23):2669–2670. doi: 10.1016/0006-2952(76)90525-6. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES