Skip to main content
NCBI home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1979 Jun;66(2):229–233. doi: 10.1111/j.1476-5381.1979.tb13670.x

Effects of beta 2-adrenoceptor stimulation on cardiac metabolism in the conscious dog.

E A Shanahan, M L Wahlqvist, E G Wilmshurst
PMCID: PMC2043634  PMID: 465875

Abstract

1 The effects of the beta 2-adrenoceptor stimulant, salbutamol, on cardiac metabolism have been studied in conscious mongrel dogs. The potential effects of anaesthesia on the study of cardiac metabolism have been avoided by prior implantation of arterial (A) and coronary sinus (CS) catheters for blood sampling and a central venous catheter for infusion. Extraction of substrates for myocardial energy metabolism (CA-CS) was assessed 3 to 24 days post-operatively. A 100 micrograms bolus of salbutamol was given followed by an infusion of 3 micrograms/min for 1 h. 2 Although heart rate increased significantly from 106 to 165 beats/min, fractional extraction of oxygen tended to fall from 84% to 77%. Thus an increase in coronary blood flow rather than in oxygen extraction must have maintained an oxygen supply commensurate with the salbutamol-induced tachycardia. 3 Neither CA-CS glucose nor fractional glucose extraction altered significantly during salbutamol infusion despite increases in arterial concentration (CA) of glucose and arterial insulin immunoreactivity and a decrease in CA of free fatty acids (FFA). This suggests that an insulin-antagonistic action accompanies the infusion of salbutamol. 4 The fractional extraction of lactate increased during salbutamol infusion. In part, this may have been a reflection of a decreased myocardial extraction of FFA with salbutamol in this model.

Full text

PDF
229

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. DUNCOMBE W. G. THE COLORIMETRIC MICRO-DETERMINATION OF NON-ESTERIFIED FATTY ACIDS IN PLASMA. Clin Chim Acta. 1964 Feb;9:122–125. doi: 10.1016/0009-8981(64)90004-x. [DOI] [PubMed] [Google Scholar]
  2. Forrester J. S., Diamond G. A., Swan H. J. Correlative classification of clinical and hemodynamic function after acute myocardial infarction. Am J Cardiol. 1977 Feb;39(2):137–145. doi: 10.1016/s0002-9149(77)80182-3. [DOI] [PubMed] [Google Scholar]
  3. Forrester J. S., Diamond G., Chatterjee K., Swan H. J. Medical therapy of acute myocardial infarction by application of hemodynamic subsets (first of two parts). N Engl J Med. 1976 Dec 9;295(24):1356–1362. doi: 10.1056/NEJM197612092952406. [DOI] [PubMed] [Google Scholar]
  4. Gibson D. G., Coltart D. J. Haemodynamic effects of intravenous salbutamol in patients with mitral valve disease: comparison with isoprenaline and atropine. Postgrad Med J. 1971 Mar;47(Suppl):40–44. [PubMed] [Google Scholar]
  5. Goldberg R., van As M., Joffe B. I., Krut L., Bersohn I., Seftel H. C. Metabolic responses to selective beta-adrenergic stimulation in man. Postgrad Med J. 1975 Feb;51(592):53–58. doi: 10.1136/pgmj.51.592.53. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. HALES C. N., RANDLE P. J. Immunoassay of insulin with insulin-antibody precipitate. Biochem J. 1963 Jul;88:137–146. doi: 10.1042/bj0880137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Imura H., Kato Y., Ikeda M., Morimoto M., Yawata M. Effect of adrenergic-blocking or -stimulating agents on plasma growth hormone, immunoreactive insulin, and blood free fatty acid levels in man. J Clin Invest. 1971 May;50(5):1069–1079. doi: 10.1172/JCI106578. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kaijser L., Lassers B. W., Wahlqvist M. L., Carlson L. A. Myocardial lipid and carbohydrate metabolism in fasting men during prolonged exercise. J Appl Physiol. 1972 Jun;32(6):847–858. doi: 10.1152/jappl.1972.32.6.847. [DOI] [PubMed] [Google Scholar]
  9. Korda A. R., Lyneham R. C., Jones W. R. The treatment of premature labour with intravenously administered salbutamol. Med J Aust. 1974 May 11;1(19):744–746. doi: 10.5694/j.1326-5377.1974.tb93296.x. [DOI] [PubMed] [Google Scholar]
  10. Lal S., Savidge R. S., Davies D. M., Ali M. M., Soni V. Intravenous salbutamol and cardiogenic shock. Lancet. 1972 Apr 15;1(7755):853–854. doi: 10.1016/s0140-6736(72)90846-x. [DOI] [PubMed] [Google Scholar]
  11. Loubatières A., Mariani M. M., Sorel G., Savi L. The action of beta-adrenergic blocking and stimulating agents on insulin secretion. Characterization of the type of beta receptor. Diabetologia. 1971 Jun;7(3):127–132. doi: 10.1007/BF01212541. [DOI] [PubMed] [Google Scholar]
  12. May C. S., Paterson J. W., Spiro S. G., Johnson A. J. Effect of intravenous injection of salbutamol in asthma. Br J Clin Pharmacol. 1975 Dec;2(6):495–501. doi: 10.1111/j.1365-2125.1975.tb00566.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Nayler W. G., McInnes I. Salbutamol and orciprenaline-induced changes in myocardial function. Cardiovasc Res. 1972 Nov;6(6):725–733. doi: 10.1093/cvr/6.6.725. [DOI] [PubMed] [Google Scholar]
  14. Nayler W. G. Some observations on the pharmacological effects of salbutamol, with particular reference to the cardiovascular system. Postgrad Med J. 1971 Mar;47(Suppl):16–21. [PubMed] [Google Scholar]
  15. Rossing R. G., Cain S. M. A nomogram relating pO2, pH, temperature, and hemoglobin saturation in the dog. J Appl Physiol. 1966 Jan;21(1):195–201. doi: 10.1152/jappl.1966.21.1.195. [DOI] [PubMed] [Google Scholar]
  16. TROUT D. L., ESTES E. H., Jr, FRIEDBERG S. J. Titration of free fatty acids of plasma: a study of current methods and a new modification. J Lipid Res. 1960 Apr;1:199–202. [PubMed] [Google Scholar]
  17. Taylor M. W., Gaddie J., Murchison L. E., Palmer K. N. Metabolic effects of oral salbutamol. Br Med J. 1976 Jan 3;1(6000):22–22. doi: 10.1136/bmj.1.6000.22. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Turnheim K., Kraupp O. Pulmonary and systemic circulatory effects and -adrenergic selectivity of hexoprenaline, salbutamol, oxyfedrine, and isoproterenol. Eur J Pharmacol. 1971 Jul;15(2):231–239. doi: 10.1016/0014-2999(71)90178-6. [DOI] [PubMed] [Google Scholar]
  19. Wahlqvist M. L., Kaijser L., Lassers B. W., Carlson L. A. Fatty acids as a determinant of myocardial substrate and oxygen metabolism in man at rest and during prolonged exercise. Acta Med Scand. 1973 Jan-Feb;193(1-2):89–96. doi: 10.1111/j.0954-6820.1973.tb10543.x. [DOI] [PubMed] [Google Scholar]
  20. Wyse S. D., Gibson D. G., Branthwaite M. A. Haemodynamic effects of salbutamol in patients needing circulatory support after open-heart surgery. Br Med J. 1974 Aug 24;3(5929):502–503. doi: 10.1136/bmj.3.5929.502. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES