Abstract
1 The effects of histamine and 4 methylhistamine (i.v.) alone, and in the presence of chlorpheniramine or cimetidine, on total lung resistance (RL), dynamic lung compliance (Cdyn) and irritant receptor activity have been studied in dogs anaesthetized with chloralose. 2 Histamine produced dose-related increases in RL and irritant receptor activity with associated falls in Cdyn which were blocked by chlorpheniramine but unaffected by cimetidine. 3 4 Methylhistamine produced small insignificant changes in RL and Cdyn and small significant increases in irritant receptor activity which were reduced with chlorpheniramine but unaffected by cimetidine. 4 The results suggest that histamine increases irritant receptor activity, either directly or indirectly, via H1-receptors.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- AMDUR M. O., MEAD J. Mechanics of respiration in unanesthetized guinea pigs. Am J Physiol. 1958 Feb;192(2):364–368. doi: 10.1152/ajplegacy.1958.192.2.364. [DOI] [PubMed] [Google Scholar]
- Ash A. S., Schild H. O. Receptors mediating some actions of histamine. Br J Pharmacol Chemother. 1966 Aug;27(2):427–439. doi: 10.1111/j.1476-5381.1966.tb01674.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Black J. W., Duncan W. A., Durant C. J., Ganellin C. R., Parsons E. M. Definition and antagonism of histamine H 2 -receptors. Nature. 1972 Apr 21;236(5347):385–390. doi: 10.1038/236385a0. [DOI] [PubMed] [Google Scholar]
- Brimblecombe R. W., Duncan W. A., Durant G. J., Ganellin C. R., Parsons M. E., Black J. W. The pharmacology of cimetidine, a new histamine H2-receptor antagonist. Br J Pharmacol. 1975 Mar;53(3):435P–436P. [PMC free article] [PubMed] [Google Scholar]
- Dixon M., Jackson D. M., Richards I. M., Vendy K. The effects of acetylcholine and histamine on total lung resistance, dynamic lung compliance and lung irritant receptor discharge in the anaesthetized dog [proceedings]. J Physiol. 1978 Feb;275:79P–80P. [PubMed] [Google Scholar]
- Paintal A. S. Vagal sensory receptors and their reflex effects. Physiol Rev. 1973 Jan;53(1):159–227. doi: 10.1152/physrev.1973.53.1.159. [DOI] [PubMed] [Google Scholar]
- Sampson S. R., Vidruk E. H. Properties of 'irritant' receptors in canine lung. Respir Physiol. 1975 Oct;25(1):9–22. doi: 10.1016/0034-5687(75)90047-x. [DOI] [PubMed] [Google Scholar]
- Vidruk E. H., Hahn H. L., Nadel J. A., Sampson S. R. Mechanisms by which histamine stimulates rapidly adapting receptors in dog lungs. J Appl Physiol Respir Environ Exerc Physiol. 1977 Sep;43(3):397–402. doi: 10.1152/jappl.1977.43.3.397. [DOI] [PubMed] [Google Scholar]
- WIDDICOMBE J. G. Receptors in the trachea and bronchi of the cat. J Physiol. 1954 Jan;123(1):71–104. doi: 10.1113/jphysiol.1954.sp005034. [DOI] [PMC free article] [PubMed] [Google Scholar]