Abstract
Myoclonus induced by catechol in the guinea-pig is not altered by manipulation of cerebral 5-hydroxytryptamine (5-HT). The administration of catechol does not alter brain levels of 5-HT or its metabolite 5-hydroxyindole acetic acid. This form of myoclonus therefore is not of relevance to the 5-HT-sensitive post-anoxic action myoclonus occurring in man.
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Angel A. An analysis of the effect of 1,2-dihydroxybenzene on transmission through the dorsal column sensory pathway. Electroencephalogr Clin Neurophysiol. 1969 Oct;27(4):392–403. doi: 10.1016/0013-4694(69)91448-5. [DOI] [PubMed] [Google Scholar]
- Angel A., Clarke K. A., Dewhurst D. G. A pharmacological study of the spontaneous convulsive activity induced by 1,2-dihydroxybenzene (catechol) in the anaesthetized mouse. Br J Pharmacol. 1977 Nov;61(3):433–439. doi: 10.1111/j.1476-5381.1977.tb08437.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Angel A., Dewhurst D. G. A pharmacological investigation of the electrically evoked convulsive activity induced by administration of catechol in the anaesthetized rat. Br J Pharmacol. 1978 Dec;64(4):539–544. doi: 10.1111/j.1476-5381.1978.tb17315.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Angel A., Dewhurst D. G. Proceedings: Effects of cholinergic drugs on catechol evoked convulsions. J Physiol. 1976 Jan;254(1):36P–37P. [PubMed] [Google Scholar]
- Angel A., Lemon R. N. An analysis of the myoclonic jerks produced by 1, 2-dihydroxybenzene in the rat. Electroencephalogr Clin Neurophysiol. 1973 Dec;35(6):589–601. doi: 10.1016/0013-4694(73)90212-5. [DOI] [PubMed] [Google Scholar]
- Angel A., Lemon R. N. Sensorimotor cortical representation in the rat and the role of the cortex in the production of sensory myoclonic jerks. J Physiol. 1975 Jun;248(2):465–488. doi: 10.1113/jphysiol.1975.sp010984. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Angel A., Lemon R. N. The convulsive action of 1,2-dihydroxybenzene in the anaesthetized rat. Electroencephalogr Clin Neurophysiol. 1973 Apr;34(4):369–378. doi: 10.1016/0013-4694(73)90088-6. [DOI] [PubMed] [Google Scholar]
- Chadwick D., Hallett M., Harris R., Jenner P., Reynolds E. H., Marsden C. D. Clinical, biochemical, and physiological features distinguishing myoclonus responsive to 5-hydroxytryptophan, tryptophan with a monoamine oxidase inhibitor, and clonazepam. Brain. 1977 Sep;100(3):455–487. doi: 10.1093/brain/100.3.455. [DOI] [PubMed] [Google Scholar]
- Chadwick D., Hallett M., Jenner P., Marsden C. D. 5-hydroxytryptophan-induced myoclonus in guinea pigs. A physiological and pharmacological investigations. J Neurol Sci. 1978 Jan;35(1):157–165. doi: 10.1016/0022-510x(78)90108-9. [DOI] [PubMed] [Google Scholar]
- Curzon G., Green A. R. Rapid method for the determination of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in small regions of rat brain. Br J Pharmacol. 1970 Jul;39(3):653–655. doi: 10.1111/j.1476-5381.1970.tb10373.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hwang E. C., Van Woert M. H. p,p'-DDT-induced neurotoxic syndrome: experimental myoclonus. Neurology. 1978 Oct;28(10):1020–1025. doi: 10.1212/wnl.28.10.1020. [DOI] [PubMed] [Google Scholar]
- Klawans H. L., Jr, Goetz C., Weiner W. J. 5-Hydroxytryptophan-induced myoclonus in guinea pigs and the possible role of serotonin in infantile myoclonus. Neurology. 1973 Nov;23(11):1234–1240. doi: 10.1212/wnl.23.11.1234. [DOI] [PubMed] [Google Scholar]
