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. 1979 Oct;67(2):173–177. doi: 10.1111/j.1476-5381.1979.tb08663.x

The protective effect of some phenothiazine derivatives against streptolysin O.

D Besluau, S Gauthier-Rahman, B Halpern
PMCID: PMC2043882  PMID: 40645

Abstract

1 Chlorpromazine (Cpz) and promethazine (Pmz) protected mice against lethal doses of streptolysin O (SLO) given intravenously. Three other phenothiazine derivatives had similar but lesser effects. 2 The protective effect developed slowly; maximal protection was obtained 4 h after subcutaneous injection of Cpz and Pmz. 3 The haemolytic activity of SLO in vitro was also inhibited by Cpz.

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Selected References

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