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. 1979 Oct;67(2):193–198. doi: 10.1111/j.1476-5381.1979.tb08666.x

Coronary anaphylaxis in vitro.

N Chand, P Eyre
PMCID: PMC2043896  PMID: 497526

Abstract

1 The reactivity of isolated coronary arteries and cardiac veins of the calf to selected chemical mediators of anaphylaxis and to sensitizing antigen (horse plasma) was studied. 2 Both the coronary arteries and cardiac veins contracted to bradykinin, 5-hydroxytryptamine (5-HT), prostaglandin E2 (PGE2), PGF2 alpha, histamine and carbachol. 3 Isoprenaline and PGE1 relaxed vessels which had been partially contracted by PGF2 alpha, PGE2, histamine, 5-HT, bradykinin, carbachol or antigen. 4 Horse plasma (antigen) contracted coronary vessels obtained from sensitized calves, but not from control calves. Subsequent antigen 'challenge' produced 'densensitization' (tachphylaxis). After 1 or 2 h of rest, the anaphylactic response partially recovered although there was no change in tissue reactivity to the exogenous agonists. 5 Specific doses of atropine, mepyramine (H1-blocker) and methysergide (5-HT antagonist) did not modify the anaphylactic reaction in coronary arteries, suggesting a negligible role for these biogenic amines. 6 Compound PRD-92-EA (a new anti-allergic agent) exhibited non-specific receptor blocking activity towards histamine, 5-HT and carbachol and inhibited the coronary anaphylactic reaction.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anhut H., Bernauer W., Peskar B. A. Radioimmunological determination of thromboxane release in cardiac anaphylaxis. Eur J Pharmacol. 1977 Jul 1;44(1):85–88. doi: 10.1016/0014-2999(77)90120-0. [DOI] [PubMed] [Google Scholar]
  2. Booth B. H., Patterson R. Electrocardiographic changes during human anaphylaxis. JAMA. 1970 Jan 26;211(4):627–631. [PubMed] [Google Scholar]
  3. Capurro N., Levi R. The heart as a target organ in systemic allergic reactions: comparison of cardiac analphylaxis in vivo and in vitro. Circ Res. 1975 Apr;36(4):520–528. doi: 10.1161/01.res.36.4.520. [DOI] [PubMed] [Google Scholar]
  4. Chand N., Eyre P. Anaphylactic contraction of pulmonary blood vessels of chicken. Br J Pharmacol. 1977 Jan;59(1):201–208. doi: 10.1111/j.1476-5381.1977.tb06995.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Chand N., Eyre P. Autacoid and anaphylactic reactivity of pulmonary and hepatic smooth musculature of the cat. Eur J Pharmacol. 1977 Oct 1;45(3):213–220. doi: 10.1016/0014-2999(77)90001-2. [DOI] [PubMed] [Google Scholar]
  6. Chand N., Eyre P. The Schultz-Dale reaction: a review. Agents Actions. 1978 Apr;8(3):171–184. doi: 10.1007/BF01966600. [DOI] [PubMed] [Google Scholar]
  7. Chand N., Eyre P. The pharmacology of anaphylaxis in the chicken intestine. Br J Pharmacol. 1976 Jul;57(3):399–408. doi: 10.1111/j.1476-5381.1976.tb07680.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Criep L. H., Woehler T. R. The heart in human anaphylaxis. Ann Allergy. 1971 Aug;29(8):399–409. [PubMed] [Google Scholar]
  9. Eyre P., Lewis A. J., Wells P. W. Acute systemic anaphylaxis in the calf. Br J Pharmacol. 1973 Mar;47(3):504–516. doi: 10.1111/j.1476-5381.1973.tb08182.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Eyre P. Pharmacology of bovine pulmonary vein anaphylaxis in vitro. Br J Pharmacol. 1971 Oct;43(2):302–311. [PMC free article] [PubMed] [Google Scholar]
  11. FURCHGOTT R. F., BHADRAKOM S. Reactions of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite and other drugs. J Pharmacol Exp Ther. 1953 Jun;108(2):129–143. [PubMed] [Google Scholar]
  12. GADDUM J. H., HAMEED K. A., HATHWAY D. E., STEPHENS F. F. Quantitative studies of antagonists for 5-hydroxytryptamine. Q J Exp Physiol Cogn Med Sci. 1955 Jan;40(1):49–74. doi: 10.1113/expphysiol.1955.sp001097. [DOI] [PubMed] [Google Scholar]
  13. Hahn F., Bernauer W. Studies on heart anaphylaxis. 3. Effect of antigen and histamine on perfused guinea-pig heart. Arch Int Pharmacodyn Ther. 1970 Mar;184(1):129–157. [PubMed] [Google Scholar]
  14. Holroyde M. C., Eyre P. Modulation of antigen-induced histamine release from bovine granulocytes by several anti-allergic agents. Int Arch Allergy Appl Immunol. 1977;53(6):515–519. doi: 10.1159/000231793. [DOI] [PubMed] [Google Scholar]
  15. Kalsner S. Endogenous prostaglandin release contributes directly to coronary artery tone. Can J Physiol Pharmacol. 1975 Aug;53(4):560–565. doi: 10.1139/y75-079. [DOI] [PubMed] [Google Scholar]
  16. LECOMTE J. Réactions anaphylactiques in vitro des artères pulmonaires du lapin. Int Arch Allergy Appl Immunol. 1958;12(6):339–346. [PubMed] [Google Scholar]
  17. Liebig R., Bernauer W., Peskar B. A. Prostaglandin, slow-reacting substance, and histamine release from anaphylactic guinea-pig hearts, and its pharmacological modification. Naunyn Schmiedebergs Arch Pharmacol. 1975;289(1):65–76. doi: 10.1007/BF00498030. [DOI] [PubMed] [Google Scholar]
  18. Needleman P., Kulkarni P. S., Raz A. Coronary tone modulation: formation and actions of prostaglandins, endoperoxides, and thromboxanes. Science. 1977 Jan 28;195(4276):409–412. doi: 10.1126/science.831285. [DOI] [PubMed] [Google Scholar]
  19. Possanza G. J., Bauen A., Stewart P. B. In vitro antagonism of the mediators of allergy by a benzopyrano-benzopyran carboxylic acid PR-D-92-EA. Int Arch Allergy Appl Immunol. 1975;49(6):789–795. doi: 10.1159/000231463. [DOI] [PubMed] [Google Scholar]

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