Abstract
1 Unilateral intrahypothalamic injection of either dopamine (10 μg) or amphetamine (10 μg) caused a fall in core temperature in the rat. Pimozide (0.5 mg/kg, i.p.) significantly reduced the hypothermic response, whereas pretreatment with phentolamine (1 mg/kg, i.p.) or methysergide (5 mg/kg, i.p.) was ineffective.
2 Systemic pretreatment with cocaine (20 mg/kg) abolished the hypothermic effect of amphetamine, but slightly enhanced the hypothermic response to dopamine.
3 Systemic pretreatment with tranylcypromine (10 mg/kg) had no significant effect on the fall in core temperature induced by either amphetamine or dopamine.
4 Intraperitoneal injection of cocaine and tranylcypromine, on their own, caused a fall in core temperature in the rat, which was significantly antagonized by either systemic or central pretreatment with pimozide. Phentolamine and methysergide failed to block the hypothermia.
5 Unilateral intrahypothalamic injection of cocaine (20 μg) or tranylcypromine (10 μg) also caused a significant fall in core temperature, which was reduced by intrahypothalamic pretreatment with pimozide (0.5 μg), but not significantly changed by pretreatment with phentolamine (25 μg) or methysergide (5 μg).
6 These results provide evidence for the presence of a dopaminergic system within the preoptic region, which mediates a lowering of core temperature in the rat.
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Selected References
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