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. 1980 Feb;68(2):235–240. doi: 10.1111/j.1476-5381.1980.tb10412.x

A calcium-dependent acetylcholine depolarization blocked by methoxyverapamil (D600) and procaine in snail neurones.

J M Israel, J M Meunier
PMCID: PMC2043914  PMID: 7357207

Abstract

1 Repetitive application of acetylcholine (ACh) revealed two types of ACh depolarization in two types of snail neurone, depending on their desensitization properties. 2 Further experiments were carried out on neurones which displayed a rapidly desensitizing response. 3 The amplitude of the response depended on the external sodium and calcium levels. 4 Procaine antagonized ACh effects with the same efficiency as atropine or hexamethonium, half maximal depression being obtained at a concentration of 10(-4) M. The blocking effect was independent of the dose of ACh. 5 The depression of the ACh-induced depolarization by cobalt ions and D600 suggests that clacium may participate in this response.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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