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. 1980 Feb;68(2):199–205. doi: 10.1111/j.1476-5381.1980.tb10408.x

Failure of anti-inflammatory steroids to inhibit prostaglandin production by rat polymorphonuclear leucocytes.

F Dray, E McCall, L J Youlten
PMCID: PMC2043921  PMID: 7357205

Abstract

1 Like rabbit polymorphonuclear (PMN) leucocytes, rat peritoneal glycogen-induced PMN leucocytes produced much greater amounts of prostaglandin when incubated with killed bacteria than in the absence of phagocytosable material. 2 Rat PMN leucocytes mainly prostaglandin E2 (PGE2), in amounts up to 17 ng/10(6) cells in 90 min incubation, some 25 times the amount produced by resting cells. 3 Indomethacin and meclofenamic acid inhibited prostaglandin production by resting and phagocytosing cells, the IC50 being of the order of 10(-6) to 10(-7) M for both drugs. 4 Hydrocortisone and dexamethasone at concentrations up to 10(-4) M did not cause significant dose-related inhibition of prostaglandin production in this system. 5 It is suggested that the phagocytosing PMN leucocyte is insensitive to the action of anti-inflammatory steroids with respect to prostaglandin production.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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