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. 1979 Nov;67(3):367–370. doi: 10.1111/j.1476-5381.1979.tb08689.x

The subdivision of beta-adrenoceptors in the cardiovascular system of the rat.

F J Imms, R L Neame, D A Powis
PMCID: PMC2043960  PMID: 227513

Abstract

1 The antagonism by the beta-adrenoceptor blocking drugs, propranolol (non-selective) and practolol (beta-selective), of the cardiovascular actions of isoprenaline has been investigated in the rat. 2 All doses of practolol (0.1, 1 and 3 mg/kg) blocked the cardio-accelerator action of isoprenaline but only the largest dose blocked the vasodilator effect. 3 All doses of propranolol (0.01, 0.03 and 0.1 mg/kg) blocked the vasodilator effect of isoprenaline but only the largest dose diminished the tachycardia. 4 It is concluded that in the rat, as in other species, beta-adrenoceptors may be subdivided into beta 1 (cardiac) and beta 2 (peripheral vascular) types.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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