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. 1980 Apr;68(4):617–624. doi: 10.1111/j.1476-5381.1980.tb10852.x

Effects of morphine on canine intestinal absorption and blood flow.

D Mailman
PMCID: PMC2044232  PMID: 7378636

Abstract

1 Intestinal absorption and blood flow were determined in anaesthetized fed or fasted dogs following rapid intravenous injections of morphine (0.01, 0.1, 1 mg/kg). 2 3H2O and 22Na were used to determine the unidirectional fluxes of Na+ and H2O from saline perfused through the ileal lumen and the clearances of 3H2O were used to determine total and absorptive site blood flow. 3 Net Na+ and H2O absorption were increased at each dose of morphine in fed but not in fasted dogs, due primarily to increased absorptive fluxes. 4 Arterial pressure was decreased by morphine but mesenteric vein pressure was little affected. Absorptive site blood flow was increased by morphine due to decreased blood flow resistance but total blood flow resistance was little affected by morphine. 5 The absorptive fluxes of Na+ and H2O were correlated with absorpitve site blood flow in both fed and fasted animals. The secretory fluxes of Na+ and H2O were correlated with estimated capiliary pressure in fasted dogs but morphine decreased the the secretory fluxes at a given capillary pressure in dogs which had been fed. 6 Naloxone (0.12 mg, i.v.) reversed the effects of morphine. The effects of morphine on the gut were reversed more slowly than on systemic blood pressure. 7 It was concluded that morphine can increase net absorption in fed dogs by a selective increase in intestinal absorptive site blood flow and thus increase absorptive fluxes by a washout effect but that there is also an epithelial effect, sensitized by feeding, which reduces the secretory fluxes of Na+ and H2O.

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Selected References

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  1. BERGER E. Y., STEELE J. M. The calculation of transfer rates in two compartment systems not in dynamic equilibrium. J Gen Physiol. 1958 Jul 20;41(6):1135–1152. doi: 10.1085/jgp.41.6.1135. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BHATTACHARYA B. K., LEWIS G. P. The release of 5-hydroxytryptamine by histamine liberators. Br J Pharmacol Chemother. 1956 Jun;11(2):202–208. doi: 10.1111/j.1476-5381.1956.tb01054.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Binder H. J. Pharmacology of laxatives. Annu Rev Pharmacol Toxicol. 1977;17:355–367. doi: 10.1146/annurev.pa.17.040177.002035. [DOI] [PubMed] [Google Scholar]
  4. Burks T. F., Long J. P. Release of intestinal 5-hydroxytryptamine by morphine and related agents. J Pharmacol Exp Ther. 1967 May;156(2):267–276. [PubMed] [Google Scholar]
  5. Folkow B. Regional adjustments of intestinal blood flow. Gastroenterology. 1967 Feb;52(2):423–432. [PubMed] [Google Scholar]
  6. Grubb M. N., Burks T. F. Selective antagonism of the intesinal stimulatory effects of morphine by isoproterenol prostalglandin E1 and theophylline. J Pharmacol Exp Ther. 1975 Jun;193(3):883–891. [PubMed] [Google Scholar]
  7. Gyand E. A., Kosterlitz H. W. Agonist and antagonist actions of morphine-like drugs on the guinea-pig isolated ileum. Br J Pharmacol Chemother. 1966 Sep;27(3):514–527. doi: 10.1111/j.1476-5381.1966.tb01864.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Konturek S. J., Pawlik W., Waluś K. M., Coy D. H., Schally A. V. Methionine-enkephalin stimulates gastric secretion and gastric mucosal blood flow. Proc Soc Exp Biol Med. 1978 Jun;158(2):156–160. doi: 10.3181/00379727-158-40161. [DOI] [PubMed] [Google Scholar]
  9. Lord J. A., Waterfield A. A., Hughes J., Kosterlitz H. W. Endogenous opioid peptides: multiple agonists and receptors. Nature. 1977 Jun 9;267(5611):495–499. doi: 10.1038/267495a0. [DOI] [PubMed] [Google Scholar]
  10. MacFerran S. N., Mailman D. Effects of glucagon on canine intestinal sodium and water fluxes and regional blood flow. J Physiol. 1977 Mar;266(1):1–12. doi: 10.1113/jphysiol.1977.sp011753. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Mailman D. Effects of vasoactive intestinal polypeptide on intestinal absorption and blood flow. J Physiol. 1978 Jun;279:121–132. doi: 10.1113/jphysiol.1978.sp012334. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Mailman D., Jordan K. The effect of saline and hyperoncotic dextran infusion on canine ileal salt and water absorption and regional blood flow. J Physiol. 1975 Oct;252(1):97–113. doi: 10.1113/jphysiol.1975.sp011136. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Powell D. W., Binder H. J., Curran P. F. Active electrolyte secretion stimulated by choleragen in rabbit ileum in vitro. Am J Physiol. 1973 Oct;225(4):781–787. doi: 10.1152/ajplegacy.1973.225.4.781. [DOI] [PubMed] [Google Scholar]
  14. Sheerin H. E., Field M. Ileal mucosal cyclic AMP and Cl secretion: serosal vs. mucosal addition of cholera toxin. Am J Physiol. 1977 Feb;232(2):E210–E215. doi: 10.1152/ajpendo.1977.232.2.E210. [DOI] [PubMed] [Google Scholar]
  15. Winne D. The influence of blood flow and water net flux on the absorption of tritiated water from the jejunum of the rat. Naunyn Schmiedebergs Arch Pharmacol. 1972;272(4):417–436. doi: 10.1007/BF00501248. [DOI] [PubMed] [Google Scholar]

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