Abstract
The effects of local perivascular application of dopamine to rat pial arterioles. (20-40 micrometer i.d.) were examined in situ, at the microcirculatory level, by use of a high-resolution closed circuit television microscope recording system. Local application of very low, physiological doses (1 to 10 pg) of dopamine to pial arterioles of the anaesthetized rat induces vasodilatation, whereas higher doses induce vasoconstriction. The magnitudes of these biphasic responses obtained in male rats were not significantly different from those obtained in female animals. Our findings support the theory that local release of this neurotransmitter amine from perivascular cells in the brain may promote local increases in cerebral blood flow.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Altura B. M. Sex and estrogens and responsiveness of terminal arterioles to neurohypophyseal hormones and catecholamines. J Pharmacol Exp Ther. 1975 May;193(2):403–412. [PubMed] [Google Scholar]
- Edvinsson L., Hardebo J. E., Harper A. M., McCulloch J., Owman C. Action of dopamine agonists on brain vessels in vitro and after in vivo microapplication. Acta Neurol Scand Suppl. 1977;64:350–351. [PubMed] [Google Scholar]
- Kuschinsky W., Wahl M. Local chemical and neurogenic regulation of cerebral vascular resistance. Physiol Rev. 1978 Jul;58(3):656–689. doi: 10.1152/physrev.1978.58.3.656. [DOI] [PubMed] [Google Scholar]
- Toda N. Influence of dopamine and noradrenaline on isolated cerebral arteries of the dog. Br J Pharmacol. 1976 Sep;58(1):121–126. doi: 10.1111/j.1476-5381.1976.tb07700.x. [DOI] [PMC free article] [PubMed] [Google Scholar]