Skip to main content
NCBI home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1980;71(2):525–528. doi: 10.1111/j.1476-5381.1980.tb10967.x

Effects of intracerebroventricular floctafenine and indomethacin on body temperature in febrile rabbits.

H Laburn, D Mitchell, J Stephen
PMCID: PMC2044448  PMID: 6110458

Abstract

1. We injected the potent prostaglandin synthesis inhibitors, floctafenine and indomethacin, intravenously and intracerebroventricularly in rabbits made febrile by intravenous injection of leucocyte pyrogen. 2. Floctafenine (75 mumol) injected intravenously failed to affect the fever, whereas indomethacin (15 mumol) markedly reduced the fever. 3. When injected into the cerebral ventricles, floctafenine was feebly antipyretic, and then only at a dose ten times the antipyretic dose of indomethacin. 4. Our results support the suggestion that floctafenine has no antipyretic action when administered peripherally. However, its lack of antipyretic effect cannot be explained solely on the grounds that it fails to cross the blood-brain barrier.

Full text

PDF
525

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bernheim H. A., Block L. H., Atkins E. Fever: pathogenesis, pathophysiology, and purpose. Ann Intern Med. 1979 Aug;91(2):261–270. doi: 10.7326/0003-4819-91-2-261. [DOI] [PubMed] [Google Scholar]
  2. Borsook D., Laburn H., Mitchell D. The febrile responses in rabbits and rats to leucocyte pyrogens of different species. J Physiol. 1978 Jun;279:113–120. doi: 10.1113/jphysiol.1978.sp012333. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Clark W. G. Mechanisms of antipyretic action. Gen Pharmacol. 1979;10(2):71–77. doi: 10.1016/0306-3623(79)90038-7. [DOI] [PubMed] [Google Scholar]
  4. Cranston W. I., Duff G. W., Hellon R. F., Mitchell D., Townsend Y. Evidence that brain prostaglandin synthesis is not essential in fever. J Physiol. 1976 Jul;259(1):239–249. doi: 10.1113/jphysiol.1976.sp011464. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Flower R. J., Vane J. R. Inhibition of prostaglandin biosynthesis. Biochem Pharmacol. 1974 May 15;23(10):1439–1450. doi: 10.1016/0006-2952(74)90381-5. [DOI] [PubMed] [Google Scholar]
  6. Kantor H. S., Hampton M. Indomethacin in submicromolar concentrations inhibits cyclic AMP-dependent protein kinase. Nature. 1978 Dec 21;276(5690):841–842. doi: 10.1038/276841a0. [DOI] [PubMed] [Google Scholar]
  7. Laburn H., Mitchell D., Rosendorff C. Effects of prostaglandin antagonism on sodium arachidonate fever in rabbits. J Physiol. 1977 May;267(2):559–570. doi: 10.1113/jphysiol.1977.sp011826. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Peterfalvi M., Deraedt R., Benzoni J., Chifflot L., Fournex R. Floctafenine, a new non-narcotic analgesic. Arch Int Pharmacodyn Ther. 1975 Jul;216(1):97–112. [PubMed] [Google Scholar]
  9. Rosendorff C., Mooney J. J. Central nervous system sites of action of a purified leucocyte pyrogen. Am J Physiol. 1971 Mar;220(3):597–603. doi: 10.1152/ajplegacy.1971.220.3.597. [DOI] [PubMed] [Google Scholar]
  10. Spławiński J. A., Wojtaszek B., Swies J. Endotoxin fever in rats: is it triggered by a decrease in breakdown of prostaglandin E2? Neuropharmacology. 1979 Feb;18(2):111–115. doi: 10.1016/0028-3908(79)90050-9. [DOI] [PubMed] [Google Scholar]
  11. Vane J. R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol. 1971 Jun 23;231(25):232–235. doi: 10.1038/newbio231232a0. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES