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. 1982 Oct;77(2):359–362. doi: 10.1111/j.1476-5381.1982.tb09305.x

Frequency-dependent depression of ganglionic transmission by propranolol and diltiazem in the superior cervical ganglion of the guinea-pig.

H Ito, K Nishi
PMCID: PMC2044597  PMID: 6291689

Abstract

1 Effects of propranolol and diltiazem on ganglionic transmission in the superior cervical ganglion of the guinea-pig were investigated with intracellular recording techniques. 2 Propranolol and diltiazem (5 X 10(-6)-10(-5) M) induced a transmission failure in the ganglion upon preganglionic nerve stimulation at high frequency (25-30 Hz) without affecting action potentials induced by direct stimulation of the soma membrane, or potentials induced by iontophoretically applied acetylecholine. 3 The results suggest that propranolol and diltiazem may act on preganglionic nerve terminals to inhibit Ca2+ influx in a frequency-dependent manner. These agents may depress excess sympathetic activity without much affecting normal ganglionic transmission.

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Selected References

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