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. 1982 Oct;77(2):239–244. doi: 10.1111/j.1476-5381.1982.tb09291.x

Peripheral toxicity of hemicholinium-3 in mice.

J J Freeman, J W Kosh, J S Parrish
PMCID: PMC2044599  PMID: 7139185

Abstract

1 The site (i.e. peripheral or central) of the toxicity produced by hemicholinium-3 in mice was investigated. 2 Hemicholinium-3 was measured fluorometrically and acetylcholine was determined by gas chromatography after intraventricular or intraperitoneal administration of hemicholinium-3. 3 Hemicholinium-3 was not detected in the brain nor were acetylcholine levels decreased in the brain after systemic administration. 4 The dose-response curve following intraventricular administration demonstrated that hemicholinium-3 was not as lethal after central administration as it was after peripheral administration. 5 Approximately 24% of a 75 microgram intraventricular dose of hemicholinium-3 was found in the periphery at death. 6 These results suggest that hemicholinium-3 manifests its toxicity primarily in the periphery.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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