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. 1982 Oct;77(2):309–317. doi: 10.1111/j.1476-5381.1982.tb09300.x

Influence of chloralose and pentobarbitone sodium on atrioventricular conduction in dogs.

P Duchene-Marullaz, R Fabry-Delaigue, G Gueorguiev, J P Kantelip
PMCID: PMC2044601  PMID: 7139190

Abstract

1 Atrial pacing at progressively increasing frequencies was performed on unanaesthetized dogs through electrodes placed aseptically in the wall of the right atrium and exteriorized in the neck region. 2 Heart rate and two atrioventricular conduction (AVC) parameters, namely the Wenckebach Point (one or two systole block at the end of expiration)- and the maximum atrioventricular conduction frequency (the frequency of pacing for which ventricles do not follow any auricular stimulation) were measured by electrocardiography. 3 Chloralose (0.08 g/kg i.v.) did not affect either heart rate or AVC but significantly reduced the effect of atropine (0.1 mg/kg i.v.) on all three parameters measured. The effect of isoprenaline (0.25 microgram kg-1min-1) remained unchanged. 4 Pentobarbitone Na (25 mg/kg i.v.) increased heart rate and usually caused the Wenckebach Point to disappear. It reduced the effects of atropine but did not modify those of isoprenaline. 5 In view of these results we suggest that pentobarbitone Na be avoided as an anaesthetic agent in AVC studies. It is possible to dispense with an anaesthetic agent if the technique described here is used.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARMSTRONG G. G., Jr, PORTER H., Jr, LANGSTON J. B. Alteration of carotid occlusion response by anesthesia. Am J Physiol. 1961 Nov;201:897–900. doi: 10.1152/ajplegacy.1961.201.5.897. [DOI] [PubMed] [Google Scholar]
  2. ARNOULD P., DUCHENE MARULLAZ P., BOULANGE M., SCHAFF G. LE TONUS DROMOTROPE DES NERFS EXTRINS'EQUES DU COEUR CHEZ LE CHIEN. C R Seances Soc Biol Fil. 1963 Oct 5;157:1069–1071. [PubMed] [Google Scholar]
  3. Arfors K. E., Arturson G., Malmberg P. Effect of prolonged chloralose anesthesia on acid-base balance and cardiovascular functions in dogs. Acta Physiol Scand. 1971 Jan;81(1):47–53. doi: 10.1111/j.1748-1716.1971.tb04876.x. [DOI] [PubMed] [Google Scholar]
  4. BARLOW G., KNOTT D. H. HEMODYNAMIC ALTERATIONS AFTER 30 MINUTES OF PENTOBARBITAL SODIUM ANESTHESIA IN DOGS. Am J Physiol. 1964 Oct;207:764–766. doi: 10.1152/ajplegacy.1964.207.4.764. [DOI] [PubMed] [Google Scholar]
  5. BROWN R. V., HILTON J. G. The effectiveness of the baroreceptor reflexes under different anesthetics. J Pharmacol Exp Ther. 1956 Oct;118(2):198–203. [PubMed] [Google Scholar]
  6. Bissett J. K., De Soyza N. D., Kane J. J., Murphy M. L. Improved intraventricular conduction of premature beats after diphenylhydantoin. Am J Cardiol. 1974 Apr;33(4):493–497. doi: 10.1016/0002-9149(74)90607-9. [DOI] [PubMed] [Google Scholar]
  7. Bissett J. K., Kane J. J., De Soyza N., Murphy M. L. Electrophysiological significance of rapid atrial pacing as a test of atrioventricular conduction. Cardiovasc Res. 1975 Sep;9(5):593–599. doi: 10.1093/cvr/9.5.593. [DOI] [PubMed] [Google Scholar]
  8. Charney A. N., Bass B. G., Buckley N. M. Cardiovascular effects of chloralose in catecholamine-depleted or receptor-blocked dogs. Arch Int Pharmacodyn Ther. 1970 Jun;185(2):397–405. [PubMed] [Google Scholar]
  9. Chiba S., Nakajima T. Effect of sodium pentobarbital on the SA nodal activity of the dog heart in vivo. Tohoku J Exp Med. 1972 Apr;106(4):381–385. doi: 10.1620/tjem.106.381. [DOI] [PubMed] [Google Scholar]
  10. Cox R. H. Influence of chloralose anesthesia on cardiovascular function in trained dogs. Am J Physiol. 1972 Sep;223(3):660–667. doi: 10.1152/ajplegacy.1972.223.3.660. [DOI] [PubMed] [Google Scholar]
  11. Cox R. H. Influence of pentobarbital anesthesia on cardiovascular function in trained dogs. Am J Physiol. 1972 Sep;223(3):651–659. doi: 10.1152/ajplegacy.1972.223.3.651. [DOI] [PubMed] [Google Scholar]
  12. DUCHENE-MARULLAZ P., VACHER J., DELORT P. CHLORALOSE ET FR'EQUENCE CARDIAQUE. C R Seances Soc Biol Fil. 1964;158:2354–2356. [PubMed] [Google Scholar]
  13. Damato A. N., Lau S. H., Helfant R. H., Stein E., Berkowitz W. D., Cohen S. I. Study of atrioventricular conduction in man using electrode catheter recordings of His bundle activity. Circulation. 1969 Mar;39(3):287–296. doi: 10.1161/01.cir.39.3.287. [DOI] [PubMed] [Google Scholar]
  14. EXLEY K. A. Depression of autonomic ganglia by barbiturates. Br J Pharmacol Chemother. 1954 Jun;9(2):170–181. doi: 10.1111/j.1476-5381.1954.tb00837.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Goldberg S. J., Linde L. M., Gaal P. G., Momma K., Takahashi M., Sarna G. Effects of barbiturates on pulmonary and systemic haemodynamics. Cardiovasc Res. 1968 Apr;2(2):136–142. doi: 10.1093/cvr/2.2.136. [DOI] [PubMed] [Google Scholar]
  16. Horwitz L. D., Bishop V. S., Stone H. L., Stegall H. F. Cardiovascular effects of low-oxygen atmospheres in conscious and anesthetized dogs. J Appl Physiol. 1969 Sep;27(3):370–373. doi: 10.1152/jappl.1969.27.3.370. [DOI] [PubMed] [Google Scholar]
  17. JOURDAN F., DUCHENE-MARULLAZ P., LEUSEN I. Innervation cardio-accélératrice et chloralose. C R Seances Soc Biol Fil. 1952 Sep;146(17-18):1323–1325. [PubMed] [Google Scholar]
  18. KRAYER O., MANDOKI J. J., MENDEZ C., RUBIO G. R. Studies on veratrum alkaloids. XVI. The action of epinephrine and of veratramine on the functional refractory period of the auriculo-ventricular transmission in the heart-lung preparation of the dog. J Pharmacol Exp Ther. 1951 Dec;103(4):412–419. [PubMed] [Google Scholar]
  19. MOE G. K., PRESTON J. B., BURLINGTON H. Physiologic evidence for a dual A-V transmission system. Circ Res. 1956 Jul;4(4):357–375. doi: 10.1161/01.res.4.4.357. [DOI] [PubMed] [Google Scholar]
  20. Manders W. T., Vatner S. F. Effects of sodium pentobarbital anesthesia on left ventricular function and distribution of cardiac output in dogs, with particular reference to the mechanism for tachycardia. Circ Res. 1976 Oct;39(4):512–517. doi: 10.1161/01.res.39.4.512. [DOI] [PubMed] [Google Scholar]
  21. NASH C. B., DAVIS F., WOODBURY R. A. Cardiovascular effects of anesthetic doses of pentobarbital sodium. Am J Physiol. 1956 Apr;185(1):107–112. doi: 10.1152/ajplegacy.1956.185.1.107. [DOI] [PubMed] [Google Scholar]
  22. O'Rourke R. A., Bishop V. S. Cardiovascular hemodynamics in the conscious dog. Am Heart J. 1971 Jan;81(1):55–60. doi: 10.1016/0002-8703(71)90054-8. [DOI] [PubMed] [Google Scholar]
  23. Olmsted F., Page I. H. Hemodynamic changes in dogs caused by sodium pentobarbital anesthesia. Am J Physiol. 1966 Apr;210(4):817–820. doi: 10.1152/ajplegacy.1966.210.4.817. [DOI] [PubMed] [Google Scholar]
  24. Rosen K. M., Rahimtoola S. H., Chuquimia R., Loeb H. S., Gunnar R. M. Electrophysiological significance of first degree atrioventricular block with intraventricular conduction disturbance. Circulation. 1971 Apr;43(4):491–502. doi: 10.1161/01.cir.43.4.491. [DOI] [PubMed] [Google Scholar]
  25. SCHAER H. THE ACTION OF SODIUM PENTOBARBITAL ON THE S-A NODAL ACTIVITY OF THE MAMMALIAN HEART. J Pharmacol Exp Ther. 1964 Sep;145:267–274. [PubMed] [Google Scholar]
  26. Scherlag B. J., Lau S. H., Helfant R. H., Berkowitz W. D., Stein E., Damato A. N. Catheter technique for recording His bundle activity in man. Circulation. 1969 Jan;39(1):13–18. doi: 10.1161/01.cir.39.1.13. [DOI] [PubMed] [Google Scholar]
  27. TOMAN J. E. P. Neuropharmacology of peripheral nerve. Pharmacol Rev. 1952 Jun;4(2):168–218. [PubMed] [Google Scholar]
  28. Urthaler F., Krames B. L., James T. N. Selective effects of pentobarbital on automaticity and conduction in the intact canine heart. Cardiovasc Res. 1974 Jan;8(1):46–57. doi: 10.1093/cvr/8.1.46. [DOI] [PubMed] [Google Scholar]
  29. VANCITTERS R. L., FRANKLIN D. L., RUSHMER R. F. LEFT VENTRICULAR DYNAMICS IN DOGS DURING ANESTHESIA WITH ALPHA-CHLORALOSE AND SODIUM PENTOBARBITAL. Am J Cardiol. 1964 Mar;13:349–354. doi: 10.1016/0002-9149(64)90451-5. [DOI] [PubMed] [Google Scholar]
  30. Vatner S. F., Higgins C. B., Franklin D., Braunwald E. Effects of a digitalis glycoside on coronary and systemic dynamics in conscious dogs. Circ Res. 1971 Apr;28(4):470–479. doi: 10.1161/01.res.28.4.470. [DOI] [PubMed] [Google Scholar]
  31. Wit A. L., Weiss M. B., Berkowitz W. D., Rosen K. M., Steiner C., Damato A. N. Patterns of atrioventricular conduction in the human heart. Circ Res. 1970 Sep;27(3):345–359. doi: 10.1161/01.res.27.3.345. [DOI] [PubMed] [Google Scholar]

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