Skip to main content
PMC home page
British Journal of Pharmacology logoLink to British Journal of Pharmacology
. 1982 Nov;77(3):443–448. doi: 10.1111/j.1476-5381.1982.tb09316.x

Histamine H2-antagonists modify gastric emptying in the rat.

G Bertaccini, C Scarpignato
PMCID: PMC2044627  PMID: 6128042

Abstract

1 Histamine H2-receptor antagonists were tested for their effect on gastric emptying in the rat. 2 At low doses all the compounds were inactive except for burimamide which delayed and ranitidine which accelerated gastric emptying. 3 At high doses burimamide, metiamide, cimetidine and oxmetidine delayed, whereas ranitidine accelerated gastric emptying; tiotidine remained ineffective. 4 Changes in emptying rate were not accompanied by changes in emptying pattern which, with all the compounds examined, proceeded, as in the controls, by apparent first order kinetics. 5 The mechanism of the ranitidine-induced acceleration of gastric emptying seemed to be connected with an interference with the cholinergic system, whereas the mechanism of cimetidine- and oxmetidine-induced slowing of gastric emptying was apparently related to cholinolytic and possibly also relaxant effects of the compounds. 6 These different effects of the various H2-blockers are consistent with the idea that changes in emptying rate are independent of H2-receptor blockade.

Full text

PDF
443

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barker L. A. Histamine H1- and muscarinic receptor antagonist activity of cimetidine and tiotidine in the guinea pig isolated ileum. Agents Actions. 1981 Dec;11(6-7):699–705. doi: 10.1007/BF01978792. [DOI] [PubMed] [Google Scholar]
  2. Bertaccini G., Coruzzi G. Azione dei bloccanti dei recettori istaminici H2 sullo sfintere esofageo inferiore (LES)nisolato di ratto. Farmaco Sci. 1981 Feb;36(2):129–134. [PubMed] [Google Scholar]
  3. Bertaccini G., Coruzzi G. Cholinergic-like effects of the new histamine H2-receptor antagonist ranitidine. Agents Actions. 1982 Apr;12(1-2):168–171. doi: 10.1007/BF01965134. [DOI] [PubMed] [Google Scholar]
  4. Bertaccini G., Impicciatore M., De Caro G. Action of caerulein and related substances on the pyloric sphincter of the anaesthetized rat. Eur J Pharmacol. 1973 Jun;22(3):320–324. doi: 10.1016/0014-2999(73)90032-0. [DOI] [PubMed] [Google Scholar]
  5. Bertaccini G., de Castiglione R., Scarpignato C. Effect of substance P and its natural analogues on gastric emptying of the conscious rat. Br J Pharmacol. 1981 Feb;72(2):221–223. doi: 10.1111/j.1476-5381.1981.tb09116.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bunce K. T., Daly M. J., Humphray J. M., Stables R. H2-receptor antagonists protect against aspirin-induced gastric lesions in the rat. Agents Actions. 1981 Apr;11(1-2):167–170. doi: 10.1007/BF01991491. [DOI] [PubMed] [Google Scholar]
  7. Coruzzi G., Scarpignato C., Zappia L., Bertaccini G. Effetto della benzquinamide sulla motilità gastrointestinale. Farmaco Prat. 1980 Sep;35(9):466–472. [PubMed] [Google Scholar]
  8. Okabe S., Takeuchi K., Murata T., Takagi K. Effects of cimetidine and atropine sulfate on gastric secretion and healing of gastric and duodenal ulcers in rats. Eur J Pharmacol. 1977 Jan 21;41(2):205–208. doi: 10.1016/0014-2999(77)90209-6. [DOI] [PubMed] [Google Scholar]
  9. Paré W. P., Glavin G. B., Vincent G. P. Effects of cimetidine on stress ulcer and gastric acid secretion in the rat. Pharmacol Biochem Behav. 1978 Jun;8(6):711–715. doi: 10.1016/0091-3057(78)90270-8. [DOI] [PubMed] [Google Scholar]
  10. REYNELL P. C., SPRAY G. H. The simultaneous measurement of absorption and transit in the gastro-intestinal tract of the rat. J Physiol. 1956 Feb 28;131(2):452–462. doi: 10.1113/jphysiol.1956.sp005474. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Scarpignato C., Bertaccini G. Bombesin delays gastric emptying in the rat. Digestion. 1981;21(2):104–106. doi: 10.1159/000198549. [DOI] [PubMed] [Google Scholar]
  12. Scarpignato C., Bertaccini G., Zimbaro G., Vitulo F. Ranitidine delays gastric emptying of solids in man. Br J Clin Pharmacol. 1982 Feb;13(2):252–253. doi: 10.1111/j.1365-2125.1982.tb01373.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Scarpignato C., Capovilla T., Bertaccini G. Action of caerulein on gastric emptying of the conscious rat. Arch Int Pharmacodyn Ther. 1980 Aug;246(2):286–294. [PubMed] [Google Scholar]
  14. Scarpignato C., Coruzzi G., Bertaccini G. Effect of histamine and related compounds on gastric emptying of the conscious rat. Pharmacology. 1981;23(4):185–191. doi: 10.1159/000137549. [DOI] [PubMed] [Google Scholar]
  15. Yeo T., Delitala G., Besser G. M., Edwards C. R. The effects of ranitidine on pituitary hormone secretion in vitro. Br J Clin Pharmacol. 1980 Aug;10(2):171–173. doi: 10.1111/j.1365-2125.1980.tb01737.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

RESOURCES