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. 1982 Nov;77(3):391–393. doi: 10.1111/j.1476-5381.1982.tb09310.x

The effect of leukotriene C4 on mucin release into the cat trachea in vivo and in vitro.

A C Peatfield, P J Piper, P S Richardson
PMCID: PMC2044631  PMID: 7139193

Abstract

We have tested the effect of leukotriene C4 (LTC4, 6 X 10(-8) to 6 X 10(-5) M) on the output of radiolabelled mucins from the trachea of the anaesthetized cat. Doses between 6 X 10(-7) M and 6 X 10(-5) M stimulated mucin release. FPL 55712 (9.5 X 10(-6) M) partially antagonized the effect of the highest dose of LTC4. Tests of LTC4 (6 X 10(-8) to 6 X 10(-6) M) on cat trachea in vitro failed to show any effect on mucin secretion. We conclude that leukotrienes may be one of the mediators of mucus secretion into the inflamed airway.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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