Abstract
1 The effects of dopamine and the dopamine receptor agonists, SK&F 38393 and bromocriptine, on renal and coronary blood flow in the anaesthetized dog were examined. Dopamine was found to dilate both vascular beds, whereas SK&F 38393 increased renal blood flow but did not have any dilator activity in the coronary vasculature. Bromocriptine did not cause vasodilatation in either vascular bed. 2 The vasodilator responses to dopamine and SK&F 38393 were significantly reduced by the dopamine receptor antagonists, ergometrine or metoclopramide. 3 It is proposed that the selective action of SK&F 38393 on the renal vasculature suggests that the dopamine receptors of the renal and coronary vascular beds may be of different types.
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Selected References
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- Bell C., Conway E. L., Lang W. J. Ergometrine and apomorphine as selective antagonists of dopamine in the canine renal vasculature. Br J Pharmacol. 1974 Dec;52(4):591–595. doi: 10.1111/j.1476-5381.1974.tb09728.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brooks H. L., Stein P. D., Matson J. L., Hyland J. W. Dopamine-induced alterations in coronary hemodynamics in dogs. Circ Res. 1969 May;24(5):699–704. doi: 10.1161/01.res.24.5.699. [DOI] [PubMed] [Google Scholar]
- Clark B. J., Scholtysik G., Flückiger E. Cardiovascular actions of bromocriptine. Acta Endocrinol Suppl (Copenh) 1978;216:75–81. [PubMed] [Google Scholar]
- Cobb F. R., McHale P. A., Bache R. J., Greenfield J. C., Jr Coronary and systemic hemodynamic effects of dopamine in the awake dog. Am J Physiol. 1972 Jun;222(6):1355–1360. doi: 10.1152/ajplegacy.1972.222.6.1355. [DOI] [PubMed] [Google Scholar]
- Cools A. R., Van Rossum J. M. Excitation-mediating and inhibition-mediating dopamine-receptors: a new concept towards a better understanding of electrophysiological, biochemical, pharmacological, functional and clinical data. Psychopharmacologia. 1976 Feb 2;45(3):243–254. doi: 10.1007/BF00421135. [DOI] [PubMed] [Google Scholar]
- Cools A. R., van Rossum J. M. Multiple receptors for brain dopamine in behavior regulation: concept of dopamine-E and dopamine-I receptors. Life Sci. 1980 Oct 6;27(14):1237–1253. doi: 10.1016/0024-3205(80)90217-9. [DOI] [PubMed] [Google Scholar]
- Costall B., Naylor R. J. The hypotheses of different dopamine receptor mechanisms. Life Sci. 1981 Jan 19;28(3):215–229. doi: 10.1016/0024-3205(81)90726-8. [DOI] [PubMed] [Google Scholar]
- Hahn R. A., Wardell J. R., Jr Renal vascular activity of SK&F 38393 and dopamine in anesthetized dogs. J Cardiovasc Pharmacol. 1980 Sep-Oct;2(5):583–593. doi: 10.1097/00005344-198009000-00008. [DOI] [PubMed] [Google Scholar]
- Kebabian J. W., Calne D. B. Multiple receptors for dopamine. Nature. 1979 Jan 11;277(5692):93–96. doi: 10.1038/277093a0. [DOI] [PubMed] [Google Scholar]
- Lokhandwala M. F., Tadepalli A. S., Jandhyala B. S. Cardiovascular actions of bromocriptine: evidence for a neurogenic mechanism. J Pharmacol Exp Ther. 1979 Dec;211(3):620–625. [PubMed] [Google Scholar]
- Pendleton R. G., Samler L., Kaiser C., Ridley P. T. Studies on renal dopamine receptors with a new agonist. Eur J Pharmacol. 1978 Sep 1;51(1):19–28. doi: 10.1016/0014-2999(78)90057-2. [DOI] [PubMed] [Google Scholar]
- Woodman O. L., Medgett I. C., Lang W. J., Rand M. J. Agonistic actions of DPI (2-(3,4-dihydroxyphenylimino)-imidazolidine) on alpha-adrenoceptors and dopamine receptors. Eur J Pharmacol. 1981 Oct 15;75(1):11–19. doi: 10.1016/0014-2999(81)90339-3. [DOI] [PubMed] [Google Scholar]